Nociception and the neonatal brain

doi:10.1016/j.siny.2019.05.008

Review

. 2019 Aug;24(4):101016.

doi: 10.1016/j.siny.2019.05.008. Epub 2019 Jun 5.

Nociception and the neonatal brain

Deniz Gursul¹, Caroline Hartley¹, Rebeccah Slater²

Affiliations

¹ Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom.
² Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom. Electronic address: rebeccah.slater@paediatrics.ox.ac.uk.

PMID: 31201139
PMCID: PMC6728629
DOI: 10.1016/j.siny.2019.05.008

Review

Nociception and the neonatal brain

Deniz Gursul et al. Semin Fetal Neonatal Med. 2019 Aug.

. 2019 Aug;24(4):101016.

doi: 10.1016/j.siny.2019.05.008. Epub 2019 Jun 5.

Authors

Deniz Gursul¹, Caroline Hartley¹, Rebeccah Slater²

Affiliations

¹ Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom.
² Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom. Electronic address: rebeccah.slater@paediatrics.ox.ac.uk.

PMID: 31201139
PMCID: PMC6728629
DOI: 10.1016/j.siny.2019.05.008

Abstract

Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological interventions. We review factors that can modulate noxious-evoked brain activity, which may impact infant pain experience, including gestational age, sex, prior pain, stress, and illness.

Keywords: Analgesia; Clinical trials; Development; Electroencephalography; Electromyography; Evoked potentials; Facial expressions; Magnetic resonance imaging; Near-infrared spectroscopy; Neonate; Neuroimaging; Nociception; Pain measurement.

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References

1. Coghill R.C., McHaffie J.G., Yen Y.-F. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci. 2003;100:8538–8542. - PMC - PubMed
1. Tracey I., Mantyh P.W. The cerebral signature for pain perception and its modulation. Neuron. 2007;55:377–391. - PubMed
1. Sellam G., Cignaccol E.L., Craigl K.D., Engbergl S. Contextual factors influencing pain response to heelstick procedures in preterm infants: what do we know? A systematic review. Eur J Pain. 2011;15 661.e1-661.e15. - PubMed
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[1] Coghill R.C., McHaffie J.G., Yen Y.-F. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci. 2003;100:8538–8542. - PMC - PubMed

[2] Coghill R.C., McHaffie J.G., Yen Y.-F. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci. 2003;100:8538–8542. - PMC - PubMed

[3] Tracey I., Mantyh P.W. The cerebral signature for pain perception and its modulation. Neuron. 2007;55:377–391. - PubMed

[4] Tracey I., Mantyh P.W. The cerebral signature for pain perception and its modulation. Neuron. 2007;55:377–391. - PubMed

[5] Sellam G., Cignaccol E.L., Craigl K.D., Engbergl S. Contextual factors influencing pain response to heelstick procedures in preterm infants: what do we know? A systematic review. Eur J Pain. 2011;15 661.e1-661.e15. - PubMed

[6] Sellam G., Cignaccol E.L., Craigl K.D., Engbergl S. Contextual factors influencing pain response to heelstick procedures in preterm infants: what do we know? A systematic review. Eur J Pain. 2011;15 661.e1-661.e15. - PubMed

[7] Waxman J.A., Pillai Riddell R.R., Tablon P., Schmidt L.A., Pinhasov A. Development of cardiovascular indices of acute pain responding in infants: a systematic review. Pain Res Manag. 2016;2016 - PMC - PubMed

[8] Waxman J.A., Pillai Riddell R.R., Tablon P., Schmidt L.A., Pinhasov A. Development of cardiovascular indices of acute pain responding in infants: a systematic review. Pain Res Manag. 2016;2016 - PMC - PubMed

[9] Craig K.D., Whitfield M.F., Grunau R.V., Linton J., Hadjistavropoulos H.D. Pain in the preterm neonate: behavioural and physiological indices. Pain. 1993;52:287–299. - PubMed

[10] Craig K.D., Whitfield M.F., Grunau R.V., Linton J., Hadjistavropoulos H.D. Pain in the preterm neonate: behavioural and physiological indices. Pain. 1993;52:287–299. - PubMed

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Nociception and the neonatal brain

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Nociception and the neonatal brain

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