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Review
. 1987 Sep-Oct:9 Suppl 5:S630-8.
doi: 10.1093/clinids/9.supplement_5.s630.

Strategies for the treatment of endotoxemia: significance of the acute-phase response

H S Warren  1 , L A Chedid
Affiliations
Review

Strategies for the treatment of endotoxemia: significance of the acute-phase response

H S Warren et al. Rev Infect Dis. 1987 Sep-Oct.

Abstract

Shock during gram-negative bacterial sepsis continues to be a major clinical problem. Its development is assumed to be due to the release of toxic lipopolysaccharide (LPS) from the bacterial cell wall. Consequently, research efforts have turned toward treatment to counteract the effects of LPS. Possibilities include methods based on the blocking of over-exuberant intrinsic host responses to LPS and on the neutralization of LPS with pharmacologic agents or passively infused antibodies directed at different parts of the molecule. Evidence exists to support the concept that some LPS-induced (acute-phase) host responses may play a role in protection against LPS.

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