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. 2019 Jul 2;30(1):1-2.
doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering  1 , Lotte C A Stiekema  2 , Sophie Bernelot Moens  2 , Simone L Verweij  2 , Boris Novakovic  3 , Koen Prange  4 , Miranda Versloot  2 , Jeanine E Roeters van Lennep  5 , Henk Stunnenberg  6 , Menno de Winther  7 , Erik S G Stroes  2 , Leo A B Joosten  8 , Mihai G Netea  9 , Niels P Riksen  10
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Free article

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering et al. Cell Metab. .
Free article

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

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