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. 2020 Aug 5;30(8):326-331.
doi: 10.2188/jea.JE20180255. Epub 2019 Jun 15.

Association Between Routine Nephropathy Monitoring and Subsequent Change in Estimated Glomerular Filtration Rate in Patients With Diabetes Mellitus: A Japanese Non-Elderly Cohort Study

Sachiko Ono  1 , Yosuke Ono  2 , Daisuke Koide  1 , Hideo Yasunaga  3
Affiliations

Association Between Routine Nephropathy Monitoring and Subsequent Change in Estimated Glomerular Filtration Rate in Patients With Diabetes Mellitus: A Japanese Non-Elderly Cohort Study

Sachiko Ono et al. J Epidemiol. .

Abstract

Backgrounds: Current guidelines recommend routine nephropathy monitoring, including microalbuminuria or proteinuria testing, for people with diabetes mellitus; however, its effect in terms of preserving renal function remains unclear. We conducted this study to examine the impact of routine nephropathy monitoring on subsequent changes in estimated glomerular filtration rate.

Methods: We retrospectively identified non-elderly individuals with diabetes mellitus based on the prescription of hypoglycemic agents from a large Japanese database (JMDC, Tokyo, Japan) of screening for lifestyle diseases linked with administrative claims data. We collected data on baseline characteristics including age, sex, comorbidity, and laboratory data. We then examined the association between routine nephropathy monitoring results and change in estimated glomerular filtration rate using a propensity-score inverse probability of treatment weighting method.

Results: Among 1,602 individuals who started taking hypoglycemic agents between 2005 and 2016, 102 (6.0%) underwent routine nephropathy monitoring during the first year of medication for diabetes mellitus. After adjusting for multiple confounding factors, there was no significant difference in subsequent estimated glomerular filtration rate changes between individuals with and without routine nephropathy monitoring (difference in percent change 0.11; 95% confidence interval -2.74 to 2.95).

Conclusion: Routine nephropathy monitoring was not associated with preserved renal function. Current recommendations for the universal application of nephropathy monitoring may have limited value to prevent renal dysfunction in non-elderly individuals with diabetes mellitus.

Keywords: albuminuria; diabetes mellitus; diabetic nephropathy; estimated glomerular filtration rate; quality indicator.

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Figures

Figure 1.
Figure 1.. Timeline of the study
Figure 2.
Figure 2.. Patient selection
See this image and copyright information in PMC

References

    1. Lin CC, Chen CC, Chen FN, et al. . Risks of diabetic nephropathy with variation in hemoglobin A1c and fasting plasma glucose. Am J Med. 2013;126:1017.e1–1017.e10. 10.1016/j.amjmed.2013.04.015 - DOI - PubMed
    1. Van Buren PN, Toto R. Current update in the management of diabetic nephropathy. Curr Diabetes Rev. 2013;9:62–77. 10.2174/157339913804143207 - DOI - PubMed
    1. Levin A, Djurdjev O, Barrett B, et al. . Cardiovascular disease in people with chronic kidney disease: getting to the heart of the matter. Am J Kidney Dis. 2001;38:1398–1407. 10.1053/ajkd.2001.29275 - DOI - PubMed
    1. Duckworth W, Abraira C, Moritz T, et al. . Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360:129–139. 10.1056/NEJMoa0808431 - DOI - PubMed
    1. Ismail-Beigi F, Craven T, Banerji MA, et al. . Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010;376:419–430. 10.1016/S0140-6736(10)60576-4 - DOI - PMC - PubMed

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