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. 2019 Mar 3;10(7):1633-1641.
doi: 10.7150/jca.26935. eCollection 2019.

Deleted in Breast Cancer 1 as a Novel Prognostic Biomarker for Digestive System Cancers: A Meta-Analysis

Jingting Liu  1 , Chunyan Meng  2 , Changcan Li  3 , Kaifeng Tang  2 , Hongchao Tang  2 , Jianhua Liao  2
Affiliations

Deleted in Breast Cancer 1 as a Novel Prognostic Biomarker for Digestive System Cancers: A Meta-Analysis

Jingting Liu et al. J Cancer. .

Abstract

Deleted in Breast Cancer 1 (DBC1/CCAR2) is a regulatory protein involved in cell survival and cancer progression. Herein, we focused on summarizing the overall prognostic value of DBC1 for digestive system cancers. Therefore, we conducted a meta-analysis based on 9 studies with 2391 patients to generated combined hazard ratios (HR) or odds ratio (OR) with its 95% confidence intervals (CI) for overall survival (OS) and clinicopathological features. Positive DBC1 expression was significantly associated with poor OS of digestive system cancers (pooled HR=1.650, 95% CI=1.087-2.504, P<0.019). Stratified analysis also verified the potential prognostic prediction of DBC1 in some subgroups, such as digestive tract cancers (pooled HR=1.685, 95% CI=1.013-2.802, P=0.044), univariate analysis method (pooled HR=2.077, 95%CI=1.221-3.533, P=0.007), publication date within five years (pooled HR=1.609, 95%CI=1.097-2.358, P =0.015), study sample size smaller than 200 (pooled HR=2.304, 95%CI=1.716-3.093, P<0.001) and cutoff value for positive tumor cells more than 50% (pooled HR=1.944, 95% CI=1.479-2.556, P<0.001). Additionally, in terms of the association between DBC1 expression and clinicopathological characteristics, DBC1 expression was correlated to age (pooled OR=0.596, 95%CI =0.467-0.761, P<0.001), WHO classification (pooled OR =3.780, 95% CI=2.303-6.205, P <0.001), Lauren classification (pooled OR=2.000, 95%CI =1.492-2.680, P<0.001), and lymph node metastasis (pooled OR=0.405, 95%CI=0.203-0.806, P=0.010). In conclusion, DBC1 could not only be an independent prognostic factor for survival of patients with digestive system cancer, but might also be a novel target for cancer therapy.

Keywords: Deleted in Breast Cancer 1; biomarker; digestive system cancer; meta-analysis; prognosis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The flow diagram of study selection and exclusion process in the meta-analysis
Figure 2
Figure 2
Forest plot of hazard ratio (HR) of overall survival (OS) for patients with digestive system cancers
Figure 3
Figure 3
Cumulative meta-analysis of DBC1 expression and OS in digestive system cancers
Figure 4
Figure 4
Sensitive analysis of overall survival (OS) for patients with digestive system cancers
Figure 5
Figure 5
Effect estimate for potential publication bias of included studies in Egger' test
See this image and copyright information in PMC

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References

    1. Bosman FT, Carneiro F, Hruban RH, WHO classification of tumours of the digestive system/ International Agency for Research on Cancer; 2010. p. 1089.
    1. Torre LA, Bray F, Siegel RL. et al. Global cancer statistics, 2012. Ca A Cancer Journal for Clinicians. 2015;65(2):87–108. - PubMed
    1. Bae JS, Park SH, Kim KM. et al. CK2α phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. International Journal of Cancer. 2015;136(4):797–809. - PubMed
    1. Zhang Y, Gu Y, Sha S. et al. DBC1 is over-expressed and associated with poor prognosis in colorectal cancer. International Journal of Clinical Oncology. 2014;19(1):106–112. - PubMed
    1. Noguchi A, Kikuchi K, Zheng H. et al. SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. Cancer Medicine. 2014;3(6):1553–1561. - PMC - PubMed