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. 2019 May 14;13(1):413.
doi: 10.4081/oncol.2019.413. eCollection 2019 Jan 14.

Thrombocytopenia in solid tumors: Prognostic significance

Majid Ghanavat  1 , Mina Ebrahimi  2 , Hassan Rafieemehr  3 , Mahmood Maniati  2 , Masumeh Maleki Behzad  2 , Saeid Shahrabi  4
Affiliations

Thrombocytopenia in solid tumors: Prognostic significance

Majid Ghanavat et al. Oncol Rev. .

Abstract

Solid tumors are a heterogeneous group of malignancies that result from out-of-control proliferation of cells. Thrombocytopenia is a common complication among patients with solid tumors that predispose them to bleeding disorders. The aim of this review article is to investigate the underlying mechanisms of the risk and incidence of thrombocytopenia in solid tumors. It can be argued that thrombocytopenia is a poor prognostic factor in solid tumors that can result from several factors such as polymorphism and mutation in some transcription factors and cytokines involved in megakaryocytic maturation or from the adverse effects of treatment. Therefore, an understanding of the exact mechanism of thrombocytopenia pathogenesis in each stage of solid tumors can help in developing therapeutic strategies to decrease bleeding complications in these malignancies.

Keywords: Thrombocytopenia; chemotherapy; cytokines polymorphism; solid tumors.

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Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

References

    1. Carlson RW, Allred DC, Anderson BO, et al. Metastatic breast cancer, version 1.2012 featured updates to the nccn guidelines. J Natl Compr Canc Net 2012;10:821-29. - PMC - PubMed
    1. Khasraw M, Faraj H, Sheikha A. Thrombocytopenia in solid tumors. Eur J Clin Med Oncol 2010;2:89-92.
    1. Khodadi E, Asnafi AA, Shahrabi S, et al. Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis. Ann Hematol 2016;95:1765-76. - PubMed
    1. Avvisati G, Tirindelli MC, Annibali O. Thrombocytopenia and hemorrhagic risk in cancer patients. Crit Rev Oncol Hematol 2003;48:S13-6. - PubMed
    1. Liebman HA. Thrombocytopenia in cancer patients. Thromb Res 2014;133:S63-9. - PubMed

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