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Editorial
. 2019 May;7(9):187.
doi: 10.21037/atm.2019.03.48.

VCAM-1+ macrophage subset as 'educators' in fetal liver for transition to definitive hematopoiesis

Pranela Rameshwar  1
Affiliations
Editorial

VCAM-1+ macrophage subset as 'educators' in fetal liver for transition to definitive hematopoiesis

Pranela Rameshwar. Ann Transl Med. 2019 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Overall summary of the findings by Li et al. (8). Shown are the generation of nascent hematopoietic stem cells (HSCs) and primitive MΦs in aorta gonad-mesonephros (AGM). The MΦs that express vascular cell adhesion molecule-1 (VCAM-1) migrates to the FL where they establish a niche in the vascular region to wait for the emerging HSCs with VCAM-1 receptor, VLA-4. The interaction between nascent HSCs and MΦs causes the HSCs to be retained in the fetal liver and this gives them a high probability to generate definitive hematopoiesis in the fetal liver. Since hematopoietic activity was noted in the bone marrow, there remains a question on the role of the VCAM-1+ MΦs in bone marrow hematopoiesis. ?, the unresolved path of MΦs to the FL.
See this image and copyright information in PMC

Comment on

  • VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche.
    Li D, Xue W, Li M, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W. Li D, et al. Nature. 2018 Dec;564(7734):119-124. doi: 10.1038/s41586-018-0709-7. Epub 2018 Nov 19. Nature. 2018. PMID: 30455424 Free PMC article.

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