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Review
. 2019 May 8:2019:1484152.
doi: 10.1155/2019/1484152. eCollection 2019.

Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

Yinghao Yu  1 , Jijun Zhao  1
Affiliations
Review

Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

Yinghao Yu et al. Biomed Res Int. .

Abstract

Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage regression. The etiology of OA is diverse, the exact pathogenesis of which remains unclear. Autophagy is a conserved maintenance mechanism in eukaryotic cells. Dysfunction of chondrocyte autophagy is regarded as a crucial pathogenesis of cartilage degradation in OA. MircoRNAs (miRNAs) are a category of small noncoding RNAs, acting as posttranscriptional modulators that regulate biological processes and cell signaling pathways via target genes. A series of miRNAs are involved in the progression of chondrocyte autophagy and are connected with numerous factors and pathways. This article focuses on the mechanisms of chondrocyte autophagy in OA and reviews the role of miRNA in their modulation. Potentially relevant miRNAs are also discussed in order to provide new directions for future research and improve our understanding of the autophagic network of miRNAs.

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Figures

Figure 1
Figure 1
miRNAs, specific targets and signaling pathways in the process of chondrocyte autophagy in OA. Note: miRNAs highlighted in red represent confirmed mechanisms while those highlighted in blue represent hypothesized mechanisms.
See this image and copyright information in PMC

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