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Case Reports
. 2019 May 13:12:2632010X19848005.
doi: 10.1177/2632010X19848005. eCollection 2019 Jan-Dec.

A Case of Sarcomatoid Renal Cell Carcinoma With Osseous Metaplasia and Papillary Renal Cell Carcinoma Metastasis

Hui Zhang  1 , Nasma K Majeed  1 , Roohollah Sharifi  2 , Grace Guzman  1
Affiliations
Case Reports

A Case of Sarcomatoid Renal Cell Carcinoma With Osseous Metaplasia and Papillary Renal Cell Carcinoma Metastasis

Hui Zhang et al. Clin Pathol. .

Abstract

Sarcomatoid renal cell carcinoma is an uncommon and aggressive renal tumor with rapid disease progression. A median survival time is only 4-9 months after diagnosis. Osteogenic differentiation is a rare feature of the tumor. Here, we present a case of renal cell carcinoma with sarcomatoid feature and osteoid differentiation, and papillary renal cell carcinoma metastasis in a 58 year-old African-American male. This is the first reported renal cell carcinoma case with the combination of sarcomatoid feature, osteoid differentiation, and papillary renal cell carcinoma metastasis.

Keywords: Aggressive renal cell carcinoma; osseous differentiation; papillary renal cell carcinoma metastasis; sarcomatoid renal cell carcinoma.

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Conflict of interest statement

Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Capsular disruption adjacent to the hilum.
Figure 2.
Figure 2.
Tumor occupies about 85% of the cut surface of the bisected kidney.
Figure 3.
Figure 3.
Sarcomatoid spindle cells.
Figure 4.
Figure 4.
Osseous metaplasia (arrow).
Figure 5.
Figure 5.
Papillary RCC with psammoma bodies. Abbreviation: RCC, renal cell carcinoma.
Figure 6.
Figure 6.
CK7 stain negative in sRCC (arrow) and positive in PRCC (circle). Abbreviations: PRCC, papillary renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma.
Figure 7.
Figure 7.
RCC Ma stain positive in both sRCC (arrow) and PRCC (circle). Abbreviations: PRCC, papillary renal cell carcinoma; RCC Ma, renal cell carcinoma marker; sRCC, sarcomatoid renal cell carcinoma.
Figure 8.
Figure 8.
CD10 stain positive in sRCC (arrow) and focally positive in PRCC (circle). Abbreviations: PRCC, papillary renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma.
Figure 9.
Figure 9.
CAIX stain focally positive in sRCC (arrow) and PRCC (circle). Abbreviations: CAIX, carbonic anhydrase IX; PRCC, papillary renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma.
Figure 10.
Figure 10.
Vimentin stain positive in sRCC (arrow) and PRCC (circle). Abbreviations: PRCC, papillary renal cell carcinoma; sRCC, sarcomatoid renal cell carcinoma.
See this image and copyright information in PMC

References

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