Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep;99(12):5606-5609.
doi: 10.1002/jsfa.9854. Epub 2019 Jul 2.

p-Cymene, a natural antioxidant, in Canadian total diet foods: occurrence and dietary exposures

Affiliations

p-Cymene, a natural antioxidant, in Canadian total diet foods: occurrence and dietary exposures

Xu-Liang Cao et al. J Sci Food Agric. 2019 Sep.

Abstract

Background: There is a lack of information on the presence of volatile organic compounds including p-cymene in foods for dietary exposure assessment. p-Cymene is a monoterpene found in many plant species, which has been used as a flavouring agent in foods and also exhibits antioxidant and antimicrobial properties. While the Joint FAO/WHO Expert Committee on Food Additives (JECFA) has no safety concerns at current levels of intake when used as a flavouring, the current study examines p-cymene levels in foods in general, not just from possible uses as a flavouring, as there could still be a potential health concern if there were high levels of exposure.

Results: 159 food composite samples from the 2014 Canadian Total Diet Study were analysed for p-cymene using a gas chromatographic-mass spectrometric method after headspace solid-phase microextraction. Concentrations of p-cymene in the composite samples of most food types were generally low, with a maximum level of 73.5 μg g-1 , detected in the composite sample of herbs and spices. Dietary exposures to p-cymene were estimated for different age groups of Canadian populations.

Conclusions: Although p-cymene was detected in various foods, estimated dietary exposures to p-cymene for different age groups are well below the human intake threshold of toxicological concern established by JECFA of 1800 μg per person per day for structural class I flavours, which includes p-cymene. © 2019 Society of Chemical Industry.

Keywords: GC-MS; SPME; dietary intake; exposure; food; headspace; p-cymene; total diet.

PubMed Disclaimer

References

REFERENCES

    1. Cao X-L, Pelletier L, Sparling M and Dabeka R, Occurrence of toluene in Canadian total diet foods and its significance to overall human exposure. Food Addit Contam Part A 35:110-117 (2018).
    1. Cao X-L, Sparling M, Pelletier L and Dabeka R, Styrene in foods and dietary exposure estimates. Food Addit Contam Part A 35:2045-2051 (2018).
    1. De Oliveira TM, de Carvalho RBB, de Costa IHF, de Oliveira GAL, de Souza AA, de Lima SG et al., Evaluation of p-cymene, a natural antioxidant. Pharm Biol 53:423-428 (2015).
    1. Marchese A, Arciola CR, Barbieri R, Silva AS, Nabazi SF, Sokeng AJT et al., Update on monoterpenes as antimicrobial agents: a particular focus on p-cymene. Materials 10:947 (2017).
    1. World Health Organization. Evaluation of certain food additives. WHO Technical Report Series 928: 63rd report of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 2005. Available: http://apps.who.int/iris/bitstream/handle/10665/43141/WHO_TRS_928.pdf;js... [29 November 2018].

MeSH terms

LinkOut - more resources