p-Cymene, a natural antioxidant, in Canadian total diet foods: occurrence and dietary exposures
- PMID: 31206173
- DOI: 10.1002/jsfa.9854
p-Cymene, a natural antioxidant, in Canadian total diet foods: occurrence and dietary exposures
Abstract
Background: There is a lack of information on the presence of volatile organic compounds including p-cymene in foods for dietary exposure assessment. p-Cymene is a monoterpene found in many plant species, which has been used as a flavouring agent in foods and also exhibits antioxidant and antimicrobial properties. While the Joint FAO/WHO Expert Committee on Food Additives (JECFA) has no safety concerns at current levels of intake when used as a flavouring, the current study examines p-cymene levels in foods in general, not just from possible uses as a flavouring, as there could still be a potential health concern if there were high levels of exposure.
Results: 159 food composite samples from the 2014 Canadian Total Diet Study were analysed for p-cymene using a gas chromatographic-mass spectrometric method after headspace solid-phase microextraction. Concentrations of p-cymene in the composite samples of most food types were generally low, with a maximum level of 73.5 μg g-1 , detected in the composite sample of herbs and spices. Dietary exposures to p-cymene were estimated for different age groups of Canadian populations.
Conclusions: Although p-cymene was detected in various foods, estimated dietary exposures to p-cymene for different age groups are well below the human intake threshold of toxicological concern established by JECFA of 1800 μg per person per day for structural class I flavours, which includes p-cymene. © 2019 Society of Chemical Industry.
Keywords: GC-MS; SPME; dietary intake; exposure; food; headspace; p-cymene; total diet.
© 2019 Society of Chemical Industry.
References
REFERENCES
-
- Cao X-L, Pelletier L, Sparling M and Dabeka R, Occurrence of toluene in Canadian total diet foods and its significance to overall human exposure. Food Addit Contam Part A 35:110-117 (2018).
-
- Cao X-L, Sparling M, Pelletier L and Dabeka R, Styrene in foods and dietary exposure estimates. Food Addit Contam Part A 35:2045-2051 (2018).
-
- De Oliveira TM, de Carvalho RBB, de Costa IHF, de Oliveira GAL, de Souza AA, de Lima SG et al., Evaluation of p-cymene, a natural antioxidant. Pharm Biol 53:423-428 (2015).
-
- Marchese A, Arciola CR, Barbieri R, Silva AS, Nabazi SF, Sokeng AJT et al., Update on monoterpenes as antimicrobial agents: a particular focus on p-cymene. Materials 10:947 (2017).
-
- World Health Organization. Evaluation of certain food additives. WHO Technical Report Series 928: 63rd report of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 2005. Available: http://apps.who.int/iris/bitstream/handle/10665/43141/WHO_TRS_928.pdf;js... [29 November 2018].
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
