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Review
. 2019 Jul;48(6):759-779.
doi: 10.1097/MPA.0000000000001335.

Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer

Jami L Saloman, Kathryn M Albers, Zobeida Cruz-Monserrate  1 , Brian M Davis, Mouad Edderkaoui  2 , Guido Eibl  3 , Ariel Y Epouhe, Jeremy Y Gedeon, Fred S Gorelick, Paul J Grippo  4 , Guy E Groblewski  5 , Sohail Z Husain  6 , Keane K Y Lai, Stephen J Pandol  2 , Aliye Uc  7 , Li Wen  8 , David C Whitcomb  9
Affiliations
Review

Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer

Jami L Saloman et al. Pancreas. 2019 Jul.

Abstract

At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the plethora of available animal models for studying exocrine pancreatic disease. In particular, the discussion focused on the challenges currently facing the field and potential solutions. That meeting culminated in this review, which describes the advantages and limitations of both common and infrequently used models of exocrine pancreatic disease, namely, pancreatitis and exocrine pancreatic cancer. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided.

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Conflict of interest statement

Disclosure

A.U. is a member of the American Board of Pediatrics, Subboard of Pediatric Gastroenterology; Associate Editor of Pancreatology; a consultant for Cystic Fibrosis Foundation. The rest of the authors declare no conflict of interest.

Figures

FIGURE 1.
FIGURE 1.
Questions that should be considered during study design when choosing an animal model.
See this image and copyright information in PMC

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