Comparative Study
doi: 10.1016/0006-291x(87)90921-1.
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase
Affiliations
- PMID: 3120710
- DOI: 10.1016/0006-291x(87)90921-1
Item in Clipboard
Comparative Study
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase
Biochem Biophys Res Commun.
.
Abstract
The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
Similar articles
-
Cloning and functional expression of poly(ADP-ribose) polymerase cDNA from Sarcophaga peregrina.Eur J Biochem. 1994 Mar 1;220(2):607-14. doi: 10.1111/j.1432-1033.1994.tb18662.x. Eur J Biochem. 1994. PMID: 8125121
-
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.J Biol Chem. 1987 Nov 25;262(33):15990-7. J Biol Chem. 1987. PMID: 2824474
-
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.Proc Natl Acad Sci U S A. 1987 Dec;84(23):8370-4. doi: 10.1073/pnas.84.23.8370. Proc Natl Acad Sci U S A. 1987. PMID: 2891139 Free PMC article.
-
[Structure of ADP-ribosylating enzyme and DNA repair].Nihon Rinsho. 1993 Nov;51(11):3051-61. Nihon Rinsho. 1993. PMID: 8277589 Review. Japanese.
-
Poly(ADP-ribose) polymerase: molecular biological aspects.Bioessays. 1991 Sep;13(9):455-62. doi: 10.1002/bies.950130905. Bioessays. 1991. PMID: 1796908 Review.
Cited by
-
Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain ("zinc fingers").Mol Gen Genet. 1992 Mar;232(2):231-9. doi: 10.1007/BF00280001. Mol Gen Genet. 1992. PMID: 1557029
-
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.Proc Natl Acad Sci U S A. 1989 May;86(10):3514-8. doi: 10.1073/pnas.86.10.3514. Proc Natl Acad Sci U S A. 1989. PMID: 2498872 Free PMC article.
-
Proteomic Analysis of the Downstream Signaling Network of PARP1.Biochemistry. 2018 Jan 30;57(4):429-440. doi: 10.1021/acs.biochem.7b01022. Epub 2018 Jan 19. Biochemistry. 2018. PMID: 29327913 Free PMC article. Review.
-
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.EMBO J. 1993 May;12(5):2109-17. doi: 10.1002/j.1460-2075.1993.tb05859.x. EMBO J. 1993. PMID: 8491199 Free PMC article.
-
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3481-5. doi: 10.1073/pnas.90.8.3481. Proc Natl Acad Sci U S A. 1993. PMID: 8475096 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
