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Comparative Study
. 1987 Oct 29;148(2):617-22.
doi: 10.1016/0006-291x(87)90921-1.

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

K Uchida  1 , T Morita, T Sato, T Ogura, R Yamashita, S Noguchi, H Suzuki, H Nyunoya, M Miwa, T Sugimura
Affiliations
Comparative Study

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

K Uchida et al. Biochem Biophys Res Commun. .

Abstract

The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

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