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Review
. 2019 Dec;21(10):423-431.
doi: 10.1016/j.micinf.2019.06.002. Epub 2019 Jun 15.

Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections

Moona Miettinen  1 , Madhukar Vedantham  1 , Arto T Pulliainen  2
Affiliations
Free article
Review

Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections

Moona Miettinen et al. Microbes Infect. 2019 Dec.
Free article

Abstract

Protein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to perturbation of cell signaling. This review summarizes the emerging data indicating that host cell ADP-ribosylating enzymes, poly(ADP-ribose) polymerases (PARPs), influence the course of a bacterial infection, in parallel to ADP-ribosylating bacterial toxins. Host cell PARP targeting could be an efficient therapeutic approach to treat certain bacterial infections, possibly by repurposing the approved or clinical trial PARP inhibitors developed for cancer therapy.

Keywords: ADP-ribosylation; ARTD; Bacteria; Immunity; Infection; PARP.

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