Review

. 2019 Sep:131:110585.

doi: 10.1016/j.fct.2019.110585. Epub 2019 Jun 15.

An overview of the bioactivity of monacolin K / lovastatin

Zixiao Xiong¹, Xiaohua Cao², Qinyou Wen³, Zhiting Chen³, Zuxin Cheng², Xinying Huang², Yangxin Zhang⁴, Chuannan Long⁵, Yi Zhang⁶, Zhiwei Huang⁷

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
² Key Laboratory of Crop Biotechnology (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, 350002, China.
³ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁴ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁵ Jiangxi Key Laboratory of Bioprocess Engineering, Jiangxi Science and Technology Normal University, Nanchang, 330013, China.
⁶ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁷ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address: hzwfau@163.com.

PMID: 31207306
DOI: 10.1016/j.fct.2019.110585

Review

An overview of the bioactivity of monacolin K / lovastatin

Zixiao Xiong et al. Food Chem Toxicol. 2019 Sep.

. 2019 Sep:131:110585.

doi: 10.1016/j.fct.2019.110585. Epub 2019 Jun 15.

Authors

Zixiao Xiong¹, Xiaohua Cao², Qinyou Wen³, Zhiting Chen³, Zuxin Cheng², Xinying Huang², Yangxin Zhang⁴, Chuannan Long⁵, Yi Zhang⁶, Zhiwei Huang⁷

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
² Key Laboratory of Crop Biotechnology (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, 350002, China.
³ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁴ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁵ Jiangxi Key Laboratory of Bioprocess Engineering, Jiangxi Science and Technology Normal University, Nanchang, 330013, China.
⁶ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
⁷ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address: hzwfau@163.com.

PMID: 31207306
DOI: 10.1016/j.fct.2019.110585

Abstract

Monacolin K (MK) is the principal active substance in Monascus-fermentation products (e.g. red yeast rice). MK is effective in reducing cholesterol levels in humans and has been widely used as a lipid-lowering drug. The mechanism for this is through a high degree of competitive inhibition of the rate-limiting enzyme HMG-CoA reductase (HMGR) in the cholesterol synthesis pathway. In addition to lowering blood lipid levels, MK also prevents colon cancer, acute myeloid leukemia and neurological disorders such as Parkinson's disease and type I neurofibromatosis. The aim of this manuscript is to comprehensively review the progress in the study of the biological activity of MK and its imechanism of action in reducing blood lipid concentration, prevention of cancer and its neuroprotective, anti-inflammatory and antibacterial properties. This review provides a reference for future applications of MK in functional foods and medicine.

Keywords: Bioactivity; Lovastatin; Monacolin K; Monascus; Red yeast rice; Statins.

PubMed Disclaimer

Cited by

Stimulating fungal cell wall integrity by exogenous β-glucanase to improve the production of fungal natural products.
Zhou T, Yu S, Xu H, Liu H, Rao Y. Zhou T, et al. Appl Microbiol Biotechnol. 2022 Nov;106(22):7491-7503. doi: 10.1007/s00253-022-12224-2. Epub 2022 Oct 14. Appl Microbiol Biotechnol. 2022. PMID: 36239763
Perspectives on Functional Red Mold Rice: Functional Ingredients, Production, and Application.
Yanli F, Xiang Y. Yanli F, et al. Front Microbiol. 2020 Nov 25;11:606959. doi: 10.3389/fmicb.2020.606959. eCollection 2020. Front Microbiol. 2020. PMID: 33324390 Free PMC article.
Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations.
AlAli M, Alqubaisy M, Aljaafari MN, AlAli AO, Baqais L, Molouki A, Abushelaibi A, Lai KS, Lim SE. AlAli M, et al. Molecules. 2021 Apr 27;26(9):2540. doi: 10.3390/molecules26092540. Molecules. 2021. PMID: 33925346 Free PMC article. Review.
Ultrasonic extraction, structural characterization, and antioxidant activity of oligosaccharides from red yeast rice.
Liu K, Xie L, Gu H, Luo J, Li X. Liu K, et al. Food Sci Nutr. 2021 Nov 24;10(1):204-217. doi: 10.1002/fsn3.2660. eCollection 2022 Jan. Food Sci Nutr. 2021. PMID: 35035922 Free PMC article.
Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin.
Na H, Zheng YY, Jia Y, Feng J, Huang J, Huang J, Wang CY, Yao G. Na H, et al. Microb Cell Fact. 2024 May 9;23(1):134. doi: 10.1186/s12934-024-02396-z. Microb Cell Fact. 2024. PMID: 38724934 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

An overview of the bioactivity of monacolin K / lovastatin

Affiliations

An overview of the bioactivity of monacolin K / lovastatin

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Research Materials

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Research Materials