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. 2019 Oct;62(10):374-379.
doi: 10.3345/kjp.2019.00185. Epub 2019 Jun 14.

The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis

Ensiyeh Jenabi  1 , Saied Bashirian  2 , Salman Khazaei  3 , Zohreh Basiri  4
Affiliations

The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis

Ensiyeh Jenabi et al. Korean J Pediatr. 2019 Oct.

Abstract

Background: Attention deficit hyperactivity disorder (ADHD) symptoms have a major impact on individuals, families, and society. Therefore identification risk factors of ADHD are a public health priority.

Purpose: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring.

Methods: The search identified studies published through December 2018 in the PubMed, Web of Science, and Scopus databases. The odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CI) extracted from eligible studies were used as the common measure of association among studies.

Results: A significant association was found between overweight women and the risk of ADHD among children with the pooled HR and OR estimates (HR, 1.27 and 95% CI, 1.17-1.37; OR, 1.28 and 95% CI, 1.15-1.40, respectively). This association was significant between obese women and the risk of ADHD among children and adolescents with the pooled estimates of HR and OR (HR, 1.65 and 95% CI, 1.55-1.76; OR, 1.42 and 95% CI, 1.23-1.61).

Conclusion: The current epidemiological studies present sufficient evidence that prepregnancy overweight and obesity are significantly associated with an increased risk of ADHD among children and adolescents. These findings provide a new approach to preventing ADHD by controlling weight gain in the prenatal period, which should be considered by policymakers.

Keywords: Attention deficit disorder with hyperactivity; Body mass index; Pregnancy.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Diagram of studies through the different phases of the metaanalysis.
Fig. 2.
Fig. 2.
Association between maternal prepregnancy overweight and risk of attention deficit disorder with hyperactivity among children. OR, odds ratio; HR, hazard ratio; CI, confidence interval.
Fig. 3.
Fig. 3.
Association between maternal prepregnancy obesity and the risk of attention deficit disorder with hyperactivity among children. OR, odds ratio; HR, hazard ratio; CI, confidence interval.
See this image and copyright information in PMC

References

    1. Adesman AR. The diagnosis and management of attention-deficit/ hyperactivity disorder in pediatric patients. Prim Care Companion J Clin Psychiatry. 2001;3:66–77. - PMC - PubMed
    1. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164:942–8. - PubMed
    1. Sciberras E, Mulraney M, Silva D, Coghill D. Prenatal risk factors and the etiology of ADHD-review of existing evidence. Curr Psychiatry Rep. 2017;19:1. - PubMed
    1. Plomp E, Van Engeland H, Durston S. Understanding genes, environment and their interaction in attention-deficit hyperactivity disorder: is there a role for neuroimaging? Neuroscience. 2009;164:230–40. - PubMed
    1. Nigg J, Nikolas M, Burt SA. Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:863–73. - PMC - PubMed

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