Review

. 2019 Nov;378(2):155-162.

doi: 10.1007/s00441-019-03046-2. Epub 2019 Jun 17.

Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

Rachel Stiner^{1

2}, Michael Alexander^{1

2

3}, Guangyang Liu^{1

2

3

4}, Wenbin Liao⁴, Yongjun Liu^{1

3

4

5}, Jingxia Yu^{1

2

3

4}, Egest J Pone^{1

3

5

6

7}, Weian Zhao^{1

3

4

5

6

7}, Jonathan R T Lakey^{8

9

10

11}

Affiliations

¹ Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA, 92697, USA.
² Department of Surgery, University of California, Irvine, 333 City Boulevard West, Suite 1600, Orange, CA, 92868, USA.
³ Department of Biomedical Engineering, University of California, Irvine, 402 E Peltason Dr, Irvine, CA, 92697, USA.
⁴ Baylx, Inc., 23 Spectrum Pointe Dr Suite 207, Lake Forest, CA, 92630, USA.
⁵ Department of Pharmaceutical Sciences, University of California, Irvine, 147 Bison Modular, Irvine, CA, 92697, USA.
⁶ Chao Family Comprehensive Cancer Center, University of California, Irvine, 101 The City Dr S, Orange, CA, 92868, USA.
⁷ Department of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
⁸ Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA, 92697, USA. jlakey@uci.edu.
⁹ Department of Surgery, University of California, Irvine, 333 City Boulevard West, Suite 1600, Orange, CA, 92868, USA. jlakey@uci.edu.
¹⁰ Department of Biomedical Engineering, University of California, Irvine, 402 E Peltason Dr, Irvine, CA, 92697, USA. jlakey@uci.edu.
¹¹ Baylx, Inc., 23 Spectrum Pointe Dr Suite 207, Lake Forest, CA, 92630, USA. jlakey@uci.edu.

PMID: 31209568
DOI: 10.1007/s00441-019-03046-2

Review

Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

Rachel Stiner et al. Cell Tissue Res. 2019 Nov.

. 2019 Nov;378(2):155-162.

doi: 10.1007/s00441-019-03046-2. Epub 2019 Jun 17.

Authors

Affiliations

¹ Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA, 92697, USA.
² Department of Surgery, University of California, Irvine, 333 City Boulevard West, Suite 1600, Orange, CA, 92868, USA.
³ Department of Biomedical Engineering, University of California, Irvine, 402 E Peltason Dr, Irvine, CA, 92697, USA.
⁴ Baylx, Inc., 23 Spectrum Pointe Dr Suite 207, Lake Forest, CA, 92630, USA.
⁵ Department of Pharmaceutical Sciences, University of California, Irvine, 147 Bison Modular, Irvine, CA, 92697, USA.
⁶ Chao Family Comprehensive Cancer Center, University of California, Irvine, 101 The City Dr S, Orange, CA, 92868, USA.
⁷ Department of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
⁸ Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA, 92697, USA. jlakey@uci.edu.
⁹ Department of Surgery, University of California, Irvine, 333 City Boulevard West, Suite 1600, Orange, CA, 92868, USA. jlakey@uci.edu.
¹⁰ Department of Biomedical Engineering, University of California, Irvine, 402 E Peltason Dr, Irvine, CA, 92697, USA. jlakey@uci.edu.
¹¹ Baylx, Inc., 23 Spectrum Pointe Dr Suite 207, Lake Forest, CA, 92630, USA. jlakey@uci.edu.

PMID: 31209568
DOI: 10.1007/s00441-019-03046-2

Abstract

In recent years, human umbilical cord blood has emerged as a rich source of stem, stromal and immune cells for cell-based therapy. Among the stem cells from umbilical cord blood, CD45+ multipotent stem cells and CD90+ mesenchymal stem cells have the potential to treat type I diabetes mellitus (T1DM), to correct autoimmune dysfunction and replenish β-cell numbers and function. In this review, we compare the general characteristics of umbilical cord blood-derived multipotent stem cells (UCB-SCs) and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and introduce their applications in T1DM. Although there are some differences in surface marker expression between UCB-SCs and UCB-MSCs, the two cell types display similar functions such as suppressing function of stimulated lymphocytes and imparting differentiation potential to insulin-producing cells (IPCs) in the setting of low immunogenicity, thereby providing a promising and safe approach for T1DM therapy.

Keywords: Immunomodulation; Insulin-producing cells; Mesenchymal stem cells; Multipotent stem cells; Type 1 diabetes mellitus; Umbilical cord blood.

PubMed Disclaimer

Cited by

Stem cell transplantation therapy for diabetic foot ulcer: a narrative review.
Shafiee S, Heidarpour M, Sabbagh S, Amini E, Saffari H, Dolati S, Meamar R. Shafiee S, et al. Asian Biomed (Res Rev News). 2021 Feb 21;15(1):3-18. doi: 10.2478/abm-2021-0002. eCollection 2021 Feb. Asian Biomed (Res Rev News). 2021. PMID: 37551298 Free PMC article. Review.
Predictors of cord blood unit cell content in a volume unrestricted large series collections: a chance for a fast and cheap multiparameter selection model.
Fumarola S, Lucarini A, Lucchetti G, Piroli L, Pierelli L. Fumarola S, et al. Stem Cell Res Ther. 2022 Jun 11;13(1):246. doi: 10.1186/s13287-022-02915-y. Stem Cell Res Ther. 2022. PMID: 35690786 Free PMC article.
Human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications: applications and research advances.
Li L, Li J, Guan H, Oishi H, Takahashi S, Zhang C. Li L, et al. Int J Med Sci. 2023 Sep 11;20(11):1492-1507. doi: 10.7150/ijms.87472. eCollection 2023. Int J Med Sci. 2023. PMID: 37790847 Free PMC article. Review.
Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study.
Kassem DH, Kamal MM. Kassem DH, et al. Stem Cell Res Ther. 2020 Nov 16;11(1):484. doi: 10.1186/s13287-020-01996-x. Stem Cell Res Ther. 2020. PMID: 33198815 Free PMC article.
Current status of clinical trials assessing mesenchymal stem cell therapy for graft versus host disease: a systematic review.
Li Y, Hao J, Hu Z, Yang YG, Zhou Q, Sun L, Wu J. Li Y, et al. Stem Cell Res Ther. 2022 Mar 4;13(1):93. doi: 10.1186/s13287-022-02751-0. Stem Cell Res Ther. 2022. PMID: 35246235 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

Affiliations

Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous