Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma

doi:10.1002/cpt.1555

. 2019 Nov;106(5):1133-1140.

doi: 10.1002/cpt.1555. Epub 2019 Jul 23.

Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma

Lesly-Anne Samedy-Bates^{1

2}, Sam S Oh¹, Thomas J Nuckton¹, Jennifer R Elhawary¹, Marquitta White¹, Tyronda Elliot¹, Andy M Zeiger¹, Celeste Eng¹, Sandra Salazar¹, Michael A LeNoir³, Kelley Meade⁴, Harold J Farber⁵, Denise Serebrisky⁶, Emerita Brigino-Buenaventura⁷, William Rodriguez-Cintron⁸, Kirsten Bibbins-Domingo¹, Rajesh Kumar⁹, Shannon Thyne¹⁰, Luisa N Borrell¹¹, José R Rodriguez-Santana¹², Maria Pino-Yanes^{13

14}, Esteban G Burchard^{1

2}

Affiliations

¹ Department of Medicine, University of California, San Francisco, California, USA.
² Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
³ Bay Area Pediatrics, Oakland, California, USA.
⁴ Children's Hospital and Research Center Oakland, Oakland, California, USA.
⁵ Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
⁶ Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York, USA.
⁷ Department of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, California, USA.
⁸ Veterans Caribbean Health Care System, San Juan, Puerto Rico, USA.
⁹ The Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
¹⁰ Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, New York, USA.
¹² Centro de Neumologia Pediatrica, Caguas, Puerto Rico, USA.
¹³ Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
¹⁴ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

PMID: 31209858
PMCID: PMC6778006
DOI: 10.1002/cpt.1555

Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma

Lesly-Anne Samedy-Bates et al. Clin Pharmacol Ther. 2019 Nov.

. 2019 Nov;106(5):1133-1140.

doi: 10.1002/cpt.1555. Epub 2019 Jul 23.

Authors

Affiliations

¹ Department of Medicine, University of California, San Francisco, California, USA.
² Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
³ Bay Area Pediatrics, Oakland, California, USA.
⁴ Children's Hospital and Research Center Oakland, Oakland, California, USA.
⁵ Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
⁶ Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York, USA.
⁷ Department of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, California, USA.
⁸ Veterans Caribbean Health Care System, San Juan, Puerto Rico, USA.
⁹ The Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
¹⁰ Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, New York, USA.
¹² Centro de Neumologia Pediatrica, Caguas, Puerto Rico, USA.
¹³ Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
¹⁴ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

PMID: 31209858
PMCID: PMC6778006
DOI: 10.1002/cpt.1555

Abstract

American Thoracic Society guidelines recommend inhaled corticosteroid (ICS) therapy, plus a short-acting bronchodilator, in patients with persistent asthma. However, few prior studies have examined the efficacy of this combination in children of all racial/ethnic groups. We evaluated the association between ICS use and bronchodilator response (BDR) in three pediatric populations with persistent asthma (656 African American, 916 Puerto Rican, and 398 Mexican American children). The association was assessed using multivariable quantile regression. After adjusting for baseline forced expiratory volume in one second and use of controller medications, ICS use was significantly associated with increased BDR only among Mexican Americans (1.56%, P = 0.028) but not African Americans (0.49%, P = 0.426) or Puerto Ricans (0.16%, P = 0.813). Our results demonstrate that ICS augmentation is disproportionate across racial/ethnic groups, where improved BDR is observed in Mexican Americans only. This study highlights the complexities of treating asthma in children, and reinforces the importance of investigating the influence of race/ethnicity on pharmacological response.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest:

The authors declared no competing interests for this work.

Cited by

Neighborhood Deprivation and Crime on Asthma Exacerbations and Utilization in Mild Adult Asthma.
Xu S, Puttock EJ, Zeiger RS, Vollmer WM, Schatz M, Crawford WW, Xie F, Chen W. Xu S, et al. J Allergy Clin Immunol Pract. 2024 Nov;12(11):2966-2974.e11. doi: 10.1016/j.jaip.2024.08.014. Epub 2024 Aug 13. J Allergy Clin Immunol Pract. 2024. PMID: 39147276
Heterogeneity of treatment effect of higher dose dexamethasone by geographic region (Europe vs. India) in patients with COVID-19 and severe hypoxemia - a post hoc evaluation of the COVID STEROID 2 trial.
Tirupakuzhi Vijayaraghavan BK, Granholm A, Myatra SN, Jha V, Hammond N, Micallef S, Munch MW, Kjær MN, Møller MH, Lange T, Perner A, Venkatesh B; COVID-STEROID 2 collaborators. Tirupakuzhi Vijayaraghavan BK, et al. Lancet Reg Health Southeast Asia. 2023 Oct 4;20:100293. doi: 10.1016/j.lansea.2023.100293. eCollection 2024 Jan. Lancet Reg Health Southeast Asia. 2023. PMID: 38234702 Free PMC article.
Dupilumab and tezepelumab in severe refractory asthma: new opportunities.
Ragnoli B, Morjaria J, Pignatti P, Montuschi P, Barbieri M, Mondini L, Ruggero L, Trotta L, Malerba M. Ragnoli B, et al. Ther Adv Chronic Dis. 2022 May 25;13:20406223221097327. doi: 10.1177/20406223221097327. eCollection 2022. Ther Adv Chronic Dis. 2022. PMID: 35655942 Free PMC article. Review.
Genetic Determinants of Poor Response to Treatment in Severe Asthma.
Figueiredo RG, Costa RS, Figueiredo CA, Cruz AA. Figueiredo RG, et al. Int J Mol Sci. 2021 Apr 20;22(8):4251. doi: 10.3390/ijms22084251. Int J Mol Sci. 2021. PMID: 33923891 Free PMC article. Review.
Type 2 chronic inflammatory diseases: targets, therapies and unmet needs.
Kolkhir P, Akdis CA, Akdis M, Bachert C, Bieber T, Canonica GW, Guttman-Yassky E, Metz M, Mullol J, Palomares O, Renz H, Ständer S, Zuberbier T, Maurer M. Kolkhir P, et al. Nat Rev Drug Discov. 2023 Sep;22(9):743-767. doi: 10.1038/s41573-023-00750-1. Epub 2023 Aug 1. Nat Rev Drug Discov. 2023. PMID: 37528191 Review.

See all "Cited by" articles

References

1. Eder W, Ege MJ & von Mutius E The asthma epidemic. N Engl J Med 355, 2226–2235 (2006). DOI: 10.1056/NEJMra054308. - DOI - PubMed
1. World Health Organization. Asthma <http://www.who.int/mediacentre/factsheets/fs307/en/> (2017). Accessed July 24 2018.
1. Akinbami LJ et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief, 1–8 (2012). - PubMed
1. Moorman JE et al. National surveillance of asthma: United States, 2001–2010. Vital Health Stat 3, 1–58 (2012). - PubMed
1. Barr RG et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 193, 386–395 (2016). DOI: 10.1164/rccm.201506-1211OC. - DOI - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

LinkOut - more resources

[1] Eder W, Ege MJ & von Mutius E The asthma epidemic. N Engl J Med 355, 2226–2235 (2006). DOI: 10.1056/NEJMra054308. - DOI - PubMed

[2] Eder W, Ege MJ & von Mutius E The asthma epidemic. N Engl J Med 355, 2226–2235 (2006). DOI: 10.1056/NEJMra054308. - DOI - PubMed

[3] World Health Organization. Asthma <http://www.who.int/mediacentre/factsheets/fs307/en/> (2017). Accessed July 24 2018.

[4] World Health Organization. Asthma <http://www.who.int/mediacentre/factsheets/fs307/en/> (2017). Accessed July 24 2018.

[5] Akinbami LJ et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief, 1–8 (2012). - PubMed

[6] Akinbami LJ et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief, 1–8 (2012). - PubMed

[7] Moorman JE et al. National surveillance of asthma: United States, 2001–2010. Vital Health Stat 3, 1–58 (2012). - PubMed

[8] Moorman JE et al. National surveillance of asthma: United States, 2001–2010. Vital Health Stat 3, 1–58 (2012). - PubMed

[9] Barr RG et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 193, 386–395 (2016). DOI: 10.1164/rccm.201506-1211OC. - DOI - PMC - PubMed

[10] Barr RG et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 193, 386–395 (2016). DOI: 10.1164/rccm.201506-1211OC. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma

Affiliations

Racial/Ethnic-Specific Differences in the Effects of Inhaled Corticosteroid Use on Bronchodilator Response in Patients With Asthma

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical