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. 2019 May 7;6(4):1608501.
doi: 10.1080/23723556.2019.1608501. eCollection 2019.

JmjC histone demethylases act as chromatin oxygen sensors

Michael Batie  1 , Sonia Rocha  1
Affiliations

JmjC histone demethylases act as chromatin oxygen sensors

Michael Batie et al. Mol Cell Oncol. .

Abstract

Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.

Keywords: HIF. transcription; Hypoxia; JmjC-histone demethylases; chromatin.

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Figures

Figure 1.
Figure 1.
Hypoxia-mediated redistribution of histone methylation across the genome. Jumonji-C (JmjC), Histone-3 (H3), lysine (K), tri-methylation (me3).
See this image and copyright information in PMC

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