doi: 10.1016/0006-8993(87)91315-1.
Dopamine-GABA interactions in the nucleus accumbens and lateral septum of the rat
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- PMID: 3121131
- DOI: 10.1016/0006-8993(87)91315-1
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Dopamine-GABA interactions in the nucleus accumbens and lateral septum of the rat
Brain Res.
.
Abstract
The relationships between dopaminergic afferents and GABAergic neurones were studied at the electron microscopic level in the rat lateral septum and nucleus accumbens by coupling 6-hydroxydopamine degeneration and gamma-aminobutyric acid (GABA) immunocytochemistry. Degenerating fibres were observed in the two regions making synaptic contact with GABA-immunoreactive and non-labelled cell bodies and dendrites. It is concluded that dopaminergic afferents to the septum and the nucleus accumbens contact, among others, a population of GABAergic cells. A similar route of regulation of the basalo-cortical and septo-hippocampal cholinergic pathways by dopaminergic afferents is proposed.
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