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Review

Esketamine for Treatment-Resistant Depression

Bryanna Nicole Tibensky, Louis de Léséleuc, Christine Perras, Lory Picheca
In: CADTH Issues in Emerging Health Technologies. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016. 176.
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Review

Esketamine for Treatment-Resistant Depression

Bryanna Nicole Tibensky et al.
Free Books & Documents

Excerpt

Methods: These bulletins are not systematic reviews and do not involve critical appraisal or include a detailed summary of study findings. Rather, they present an overview of the technology and available evidence. They are not intended to provide recommendations for or against a particular technology.

Literature Search: A limited literature search was conducted using the following bibliographic databases: MEDLINE, Embase, PsychInfo, PubMed, and the Cochrane Library. Grey literature was identified by searching relevant sections of the Grey Matters checklist (https://www.cadth.ca/grey-matters). No methodological filters were applied. The search was limited to English-language documents but not limited by publication year. Regular alerts updated the search until project completion; only citations retrieved before March 13, 2019 were incorporated into the analysis.

Study Selection: One author screened the literature search results and reviewed the full text of all potentially relevant studies. Studies were considered for inclusion if the intervention was esketamine (S-ketamine) and studied for treatment-resistant depression in a phase III trial. Conference abstracts and grey literature were included when they provided additional information to that available in the published studies.

Peer Review: A draft version of this bulletin was reviewed by one clinical expert. The drug manufacturer also provided input on an earlier draft of this report.

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