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. 2019 Dec;17(6):598-602.
doi: 10.1089/bio.2019.0022. Epub 2019 Jun 18.

Great Lakes Biorepository Research Network's Annual Biobanking Symposium: A Focus on Precision Medicine

Joseph D Paulauskis  1 , Victoria M Blanc  1 , Thomas Carey  1 , David W Chesla  2 , Renée C Frey  1 , Timothy Geddes  3 , Jonathan Keats  4 , Allan Loup  1 , Barbara Pruetz  3 , Daniel C Rohrer  5 , Dana R Valley  5 , Tom Tomlinson  6 , Jan Akervall  3   7 , George D Wilson  3 , Scott D Jewell  5
Affiliations

Great Lakes Biorepository Research Network's Annual Biobanking Symposium: A Focus on Precision Medicine

Joseph D Paulauskis et al. Biopreserv Biobank. 2019 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

No conflicting financial interests exist.

Figures

FIG. 1.
FIG. 1.
The GLBRN leadership team—pictured from the left are George Wilson, Scott Jewell, Dan Rohrer, Tom Carey, Tim Geddes, Victoria Blanc, Barbara Pruetz, and Tom Tomlinson. GLBRN, Great Lakes Biorepository Research Network.
FIG. 2.
FIG. 2.
Jonathan Keats, PhD, Assistant Professor and Director of Bioinformatics at TGen (Phoenix, AZ), received an enthusiastic response from the audience for his keynote address “Molecular Signatures in Multiple Myeloma: The Multiple Myeloma Research Foundation (MMRF) CoMMpass Study.” Dr Keats discussed why multiple myeloma is a great model disease for precision medicine because assessing the disease cell type is aided by the fact that normal plasma cells are rare in bone marrow (<2%), tumor cells can be enriched, average 94% purity (CD138), tumor cell secrets a natural, easily monitored biomarker(s), can be defined with benign precursor diseases, monoclonal gammopathy of unknown significance (MGUS), and smoldering multiple myeloma (MM).
FIG. 3.
FIG. 3.
Dave W. Chesla, PA-ASCP, MHA, Director, Research Operations Spectrum Health Universal Biorepository, also presented a keynote address titled “All of Us—Historical and Latest Developments.” As an example, a robust QC process is critical for biobanks with formalin-fixed paraffin-embedded (FFPE) tissues. Researchers may use curls, unstained slides for macro dissection of tissues or extract cores from a block, and if QC process is not in place, cross-contamination/floaters may confound data derived from sequencing techniques. QC, quality control.
See this image and copyright information in PMC

References

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    1. Foulk B, Schaffer M, Gross S, et al. . Enumeration and characterization of circulating multiple myeloma cells in patients with plasma cell disorders. Br J Haematol 2018;180:71–81 - PubMed
    1. Laganà A, Perumal D, Melnekoff D, et al. . Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Leukemia 2018;32:120–130 - PubMed
    1. Lazzari E, Mondala PK, Santos ND, et al. . Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun 2017;8:1922. - PMC - PubMed
    1. Manojlovic Z, Christofferson A, Liang WS, et al. . Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases. PLoS Genet 2017;13:e1007087. - PMC - PubMed

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