Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence

Affiliations

¹ C. Louwrens Braal, PharmD, Erasmus University Medical Center, Rotterdam, the Netherlands; Jos H. Beijnen, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; Stijn L.W. Koolen, PhD, PharmD and Esther Oomen-de Hoop, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Neeltje Steeghs, MD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Agnes Jager, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Alwin D.R. Huitema, PharmD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; and Ron H.J. Mathijssen, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands.

Comment

C Louwrens Braal et al. J Clin Oncol. 2019.

. 2019 Aug 1;37(22):1980-1981.

doi: 10.1200/JCO.19.00418. Epub 2019 Jun 18.

¹ C. Louwrens Braal, PharmD, Erasmus University Medical Center, Rotterdam, the Netherlands; Jos H. Beijnen, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; Stijn L.W. Koolen, PhD, PharmD and Esther Oomen-de Hoop, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Neeltje Steeghs, MD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Agnes Jager, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands; Alwin D.R. Huitema, PharmD, PhD, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, the Netherlands, and Utrecht University, Utrecht, the Netherlands; and Ron H.J. Mathijssen, MD, PhD, Erasmus University Medical Center, Rotterdam, the Netherlands.

No abstract available

Comment on

Tamoxifen Pharmacogenetics and Metabolism: Results From the Prospective CYPTAM Study.
Sanchez-Spitman A, Dezentjé V, Swen J, Moes DJAR, Böhringer S, Batman E, van Druten E, Smorenburg C, van Bochove A, Zeillemaker A, Jongen L, Los M, Neven P, Gelderblom H, Guchelaar HJ. Sanchez-Spitman A, et al. J Clin Oncol. 2019 Mar 10;37(8):636-646. doi: 10.1200/JCO.18.00307. Epub 2019 Jan 24. J Clin Oncol. 2019. PMID: 30676859 Clinical Trial.