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Comment
. 2019 Aug 1;37(22):1982-1983.
doi: 10.1200/JCO.19.00504. Epub 2019 Jun 18.

Tamoxifen Metabolism and Breast Cancer Recurrence: A Question Unanswered by CYPTAM

Matthew P Goetz  1 , Vera J Suman  1 , Yusuke Nakamura  1 , Kazuma Kiyotani  1 , V Craig Jordan  1 , James N Ingle  1
Affiliations
Comment

Tamoxifen Metabolism and Breast Cancer Recurrence: A Question Unanswered by CYPTAM

Matthew P Goetz et al. J Clin Oncol. .
No abstract available

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References

    1. Sanchez-Spitman A, Dezentjé V, Swen J, et al. Tamoxifen pharmacogenetics and metabolism: Results from the prospective CYPTAM study. J Clin Oncol. 2019;37:636–646. - PubMed
    1. Kiyotani K, Mushiroda T, Zembutsu H, et al. Important and critical scientific aspects in pharmacogenomics analysis: Lessons from controversial results of tamoxifen and CYP2D6 studies. J Hum Genet. 2013;58:327–333. - PubMed
    1. Goetz MP, Rae JM, Suman VJ, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005;23:9312–9318. - PubMed
    1. Province MA, Goetz MP, Brauch H, et al. CYP2D6 genotype and adjuvant tamoxifen: Meta-analysis of heterogeneous study populations. Clin Pharmacol Ther. 2014;95:216–227. - PMC - PubMed
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