Comment

. 2019 Jun 17;49(6):827-828.

doi: 10.1016/j.devcel.2019.05.039.

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

Carly R Cabel¹, Elaheh Alizadeh¹, David J Robbins², Yashi Ahmed³, Ethan Lee⁴, Curtis A Thorne⁵

Affiliations

¹ Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
² Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
³ Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA. Electronic address: yashi.ahmed@dartmouth.edu.
⁴ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: ethan.lee@vanderbilt.edu.
⁵ Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA. Electronic address: curtisthorne@email.arizona.edu.

PMID: 31211991
PMCID: PMC6613640
DOI: 10.1016/j.devcel.2019.05.039

Comment

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

Carly R Cabel et al. Dev Cell. 2019.

. 2019 Jun 17;49(6):827-828.

doi: 10.1016/j.devcel.2019.05.039.

Authors

Carly R Cabel¹, Elaheh Alizadeh¹, David J Robbins², Yashi Ahmed³, Ethan Lee⁴, Curtis A Thorne⁵

Affiliations

¹ Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
² Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
³ Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA. Electronic address: yashi.ahmed@dartmouth.edu.
⁴ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: ethan.lee@vanderbilt.edu.
⁵ Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA. Electronic address: curtisthorne@email.arizona.edu.

PMID: 31211991
PMCID: PMC6613640
DOI: 10.1016/j.devcel.2019.05.039

No abstract available

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Conflict of interest statement

DECLARATION OF INTERESTS

E.L. and D.J.R. are co-founders of StemSynergy Therapeutics Inc., a company that seeks to develop inhibitors of major signaling pathways (including the Wnt pathway) for the treatment of cancer.

Comment on

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E. Saito-Diaz K, et al. Dev Cell. 2018 Mar 12;44(5):566-581.e8. doi: 10.1016/j.devcel.2018.02.013. Dev Cell. 2018. PMID: 29533772 Free PMC article.
APC Deficiency Leads to β-Catenin Stabilization and Signaling Independent of LRP5/6.
Chen M, He X. Chen M, et al. Dev Cell. 2019 Jun 17;49(6):825-826. doi: 10.1016/j.devcel.2019.05.013. Dev Cell. 2019. PMID: 31211990 No abstract available.

References

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1. Clevers H, and Nusse R (2012). Wnt/b-catenin signaling and disease. Cell 149, 1192–1205. - PubMed
1. El-Brolosy MA, and Stainier DYR (2017). Genetic compensation: A phenomenon in search of mechanisms. PLoS Genet. 13, e1006780. - PMC - PubMed
1. Krumins AM, and Gilman AG (2006). Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins. J. Biol. Chem 281, 10250–10262. - PubMed
1. Liu Y, Mi Y, Mueller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, et al. (2019). Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nat. Biotechnol 37, 314–322. - PubMed

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Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

Affiliations

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

Authors

Affiliations

Conflict of interest statement

Comment on

References

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Grants and funding

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