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Review
. 2019 Jun;144(12):842-849.
doi: 10.1055/a-0882-7530. Epub 2019 Jun 18.

[Clostridium Difficile: Monoclonal Antibody Therapy and Vaccines]

[Article in German]
Emil Christian Reisinger, Meinolf Ebbers, Micha Löbermann
Review

[Clostridium Difficile: Monoclonal Antibody Therapy and Vaccines]

[Article in German]
Emil Christian Reisinger et al. Dtsch Med Wochenschr. 2019 Jun.

Abstract

Hospital-acquired Clostridium difficile infections have become much more frequent in recent years. Besides treatment with antibiotics and fecal microbiota transplant, new preventive strategies are available now. Bezlotoxumab is an antibody against toxin B and may reduce the risk of relapse by roughly 10 %. Several vaccine candidates against toxins A and B and surface-associated antigens were immunogenic and are tested in clinical trials to investigate the efficacy and safety.

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Conflict of interest statement

ML: Prüfer bei klinischen Studien (Valneva, Pfizer, GSK, Themis Bioscience), Vortragshonorar Astellas, Janssen, Roche.ECR: Prüfer bei klinischen Studien (Valneva, Pfizer, GSK, Themis Bioscience), Vortragshonorar Roche, Infectopharm.

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