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Review
. 2019 Jun 11;9(6):225.
doi: 10.3390/biom9060225.

Bioactivities of Halometabolites from Marine Actinobacteria

Noer Kasanah  1   2 , Triyanto Triyanto  3   4
Affiliations
Review

Bioactivities of Halometabolites from Marine Actinobacteria

Noer Kasanah et al. Biomolecules. .

Abstract

Natural halogenated compounds (halometabolites) are produced mainly by marine organisms, including marine Actinobacteria. Many commercially important compounds for pharmaceuticals contain halogen, and the halogen is responsible for the physical and chemical properties as well as bioactivities and toxicities. In the exploration of marine environment that is supported by advanced structure elucidation, varied panel bioassays and high-throughput screening have accelerated number of halometabolites isolated from marine Actinobacteria to date. The metabolites exhibited unique structures and promising bioactivities. This review focuses on the chemodiversity and bioactivities of marine halometabolites from marine Actinobacteria reported in the last 15 years (2003-2018).

Keywords: antibacteria; anticancer; chemodiversity; halometabolites; marine actinobacteria.

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Conflict of interest statement

The authors declare no conflict of interest. And the funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Halometabolites from terrestrial Actinobacteria.
Figure 1
Figure 1
Halometabolites from terrestrial Actinobacteria.
Figure 2
Figure 2
Halogenated alkaloid.
Figure 2
Figure 2
Halogenated alkaloid.
Figure 3
Figure 3
Halogenated terpene and monoterpene.
Figure 3
Figure 3
Halogenated terpene and monoterpene.
Figure 3
Figure 3
Halogenated terpene and monoterpene.
Figure 4
Figure 4
Halogenated peptides.
Figure 5
Figure 5
Halogenated polyketide.
Figure 5
Figure 5
Halogenated polyketide.
See this image and copyright information in PMC

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