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. 2019 Jun 12;20(12):2857.
doi: 10.3390/ijms20122857.

Non-Ionic Deep Eutectic Liquids: Acetamide-Urea Derived Room Temperature Solvents

Subramanian Suriyanarayanan  1 , Gustaf D Olsson  2 , Subban Kathiravan  3 , Natacha Ndizeye  4 , Ian A Nicholls  5
Affiliations

Non-Ionic Deep Eutectic Liquids: Acetamide-Urea Derived Room Temperature Solvents

Subramanian Suriyanarayanan et al. Int J Mol Sci. .

Abstract

A family of non-ionic deep eutectic liquids has been developed based upon mixtures of solid N-alkyl derivatives of urea and acetamide that in some cases have melting points below room temperature. The eutectic behaviour and physical characteristics of a series of eleven eutectic mixtures are presented, along with a molecular dynamics study-supported hypothesis for the origin of the non-ideal mixing of these substances. Their use as solvents in applications ranging from natural product extraction to organic and polymer synthesis are demonstrated.

Keywords: acetamide–urea; deep-eutectic solvent; flickering cluster.

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Conflict of interest statement

There are no conflict to declare.

Figures

Figure 1
Figure 1
Structure of suggested flickering cluster-like complexes of (1) A–U and (2) NMA–NN’DMU.
Scheme 1
Scheme 1
Copper catalyzed click reaction of benzyl bromide (3) and 4-methoxy phenyl acetylene (4) to yield 1-benzyl-4-(4-metoxyphenyl)-1H-1,2,3-triazole (5).
Figure 2
Figure 2
(A) Infrared spectra. (B) Nitrogen adsorption-desorption isotherms and (C) pore distribution plot (desorption) observed from BET adsorption isotherm experiments. (D,E) Scanning electron micrographs, respectively, of MAA–BAP copolymer synthesized in NMA–NMU eutectic system and water.
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