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. 2019 May 23:12:1385-1391.
doi: 10.2147/IDR.S203813. eCollection 2019.

Lipid profile improvement in virologically suppressed HIV-1-infected patients switched to dolutegravir/abacavir/lamivudine: data from the SCOLTA project

Paola Bagella  1 , Nicola Squillace  2 , Elena Ricci  3 , Roberto Gulminetti  4 , Giuseppe Vittorio De Socio  5 , Lucia Taramasso  6 , Giovanni Pellicanò  7 , Barbara Menzaghi  8 , Benedetto Maurizio Celesia  9 , Chiara Dentone  10 , Giancarlo Orofino  11 , Paolo Bonfanti  12 , Giordano Madeddu  13
Affiliations

Lipid profile improvement in virologically suppressed HIV-1-infected patients switched to dolutegravir/abacavir/lamivudine: data from the SCOLTA project

Paola Bagella et al. Infect Drug Resist. .

Abstract

Introduction: Metabolic disorders are common amongst HIV-infected patients. Data from real-life setting on the impact of DTG/ABC/3TC in virologically suppressed HIV-infected patients are scarce. Methods: We investigated the modification of metabolic profile including fasting glucose, lipid profile and markers of insulin resistance (IR) in experienced patients switching from a boosted protease inhibitors (bPI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen to DTG/ABC/3TC in a prospective, observational, multicenter study. Results: We enrolled 131 HIV-infected patients, of whom 91 (69.5%) males, mean age was 50.5±10.6 years. CDC stage was A in 66 (50.4%) patients, of whom 91 (69.5%) had acquired HIV through sexual contacts. The previous regimen was bPI-based in 79 patients (60.3%) and NNRTI-based in 52 (39.7%). Patients switching from NNRTI showed a significant reduction at week 24 in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). Triglycerides/high-density lipoprotein cholesterol (TG/HDL) ratio, HDL, median TG and TG/HDL ratio did not show significant modification during follow-up times. Among patients switching from a bPI, we observed a significant reduction in TC and LDL at both follow-up times and a slight increase in HDL. Triglycerides/HDL ratio, median TG and TG/HDL ratio showed a decrease over time that became significant at weeks 24 and 48. Blood glucose levels did not significantly vary during the observation period in patients switching from both bPI and NNRTI-based regimens. Conclusion: Our data suggest an improvement in lipid profile and TG/HDL ratio in pretreated HIV-1-infected patients who switched to DTG/ABC/3TC over 48 weeks, especially in those previously receiving a bPI-based regimen.

Keywords: HIV-1 infection; dolutegravir/abacavir/lamivudine; lipid profile.

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Conflict of interest statement

GM has acted as advisor for Gilead Sciences, Janssen and Merck Sharp and Dohme and ViiV Healthcare and has received speakers’ honoraria from Gilead Sciences, Merck Sharp and Dohme, Janssen and ViiV Healthcare. NS has received travel grants from Gilead Sciences, Janssen, and ViiV Healthcare. ER declares consultancy fees from ViiV Healthcare. GVDS has received speakers’ honoraria from Gilead Sciences, Merck Sharp and Dohme, Janssen and ViiV Healthcare. LT has received consultancy fees from Janssen and Abbvie. He also reports personal fees from ViiV and Janssen, outside the submitted work. BMC has received grants, travel grants and speakers’ honoraria from bbvie, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, Janssen and ViiV Healthcare. PBo has received personal fees from Gilead Sciences, Merck Sharp and Dohme, Janssen and ViiV Healthcare. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Changes from baseline to 24 (T1) and 48 (T2) weeks in total cholesterol (TC), high-density lipoprotein (HDL), TC/HDL ratio, low-density lipoprotein (LDL), triglycerides (TG) and TG/HDL ratio. Data are shown as a mean change from baseline for TC, HDL, TC/HDL, LDL, TG and median change from baseline for TG/HDL. Abbreviations: bPI, boosted protease Inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitors.
See this image and copyright information in PMC

References

    1. Guaraldi G, Orlando G, Zona S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53:1120–1126. doi:10.1093/cid/cir522 - DOI - PubMed
    1. d’Ettorre G, Ceccarelli G, Pavone P, et al. What happens to cardiovascular system behind the undetectable level of HIV viremia? AIDS Res Ther. 2016;13:21. doi:10.1186/s12981-016-0105-z - DOI - PMC - PubMed
    1. Tavoschi L, Gomes Dias J, Pharris A; EU/EEA HIV Surveillance Network. New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004-15: an analysis of surveillance data. Lancet HIV. 2017:4(11):e514–e521. - PubMed
    1. European AIDS clinical Society. Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Version 9.0 November 2017; 2017.
    1. Trottier B, Lake JE, Logue K, et al. Dolutegravir/abacavir/lamivudine versus current ART in virally suppressed patients (STRIIVING): a 48-week, randomized, non-inferiority, open-label, phase IIIb study. Antivir Ther. 2017;22(4):295–305. - PubMed