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Review
. 2019 Jul 1;48(13):3497-3512.
doi: 10.1039/c9cs00197b.

New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Philipp Stockmann  1 , Marta Gozzi, Robert Kuhnert, Menyhárt B Sárosi, Evamarie Hey-Hawkins
Affiliations
Review

New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Philipp Stockmann et al. Chem Soc Rev. .

Abstract

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

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