Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu^{1

2}, Xing-Rong Peng¹, Da-Shan Li¹, Qiang-Qiang Shi^{1

2}, Ming-Hua Qiu^{3

4

5}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, 650204, People's Republic of China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, 650204, People's Republic of China. mhchiu@mail.kib.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. mhchiu@mail.kib.ac.cn.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 LanHei Road, Kunming, 650201, Yunnan, People's Republic of China. mhchiu@mail.kib.ac.cn.

PMID: 31214880
PMCID: PMC6646490
DOI: 10.1007/s13659-019-0214-1

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu et al. Nat Prod Bioprospect. 2019 Aug.

. 2019 Aug;9(4):303-310.

doi: 10.1007/s13659-019-0214-1. Epub 2019 Jun 18.

Authors

Jing Lu^{1

2}, Xing-Rong Peng¹, Da-Shan Li¹, Qiang-Qiang Shi^{1

2}, Ming-Hua Qiu^{3

4

5}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, 650204, People's Republic of China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, 650204, People's Republic of China. mhchiu@mail.kib.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. mhchiu@mail.kib.ac.cn.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 LanHei Road, Kunming, 650201, Yunnan, People's Republic of China. mhchiu@mail.kib.ac.cn.

PMID: 31214880
PMCID: PMC6646490
DOI: 10.1007/s13659-019-0214-1

Abstract

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from the mother liquid. The chemical structures of new compounds (1-4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC₅₀ values ranging from 4.02 to 15.80 μM.

Keywords: Cimicifuga foetida; Cycloartane triterpenoid saponins; Cytotoxic activity.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

**Fig. 3**
Key correlations in 2D NMR spectra of compound 1

**Fig. 4**
Key correlations in 2D NMR spectra of compound 3

**Fig. 5**
Key correlations in 2D NMR spectra of compound 4

See this image and copyright information in PMC

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Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Affiliations

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Authors

Affiliations

Abstract

Conflict of interest statement

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