Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug;9(4):303-310.
doi: 10.1007/s13659-019-0214-1. Epub 2019 Jun 18.

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu  1   2 , Xing-Rong Peng  1 , Da-Shan Li  1 , Qiang-Qiang Shi  1   2 , Ming-Hua Qiu  3   4   5
Affiliations

Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida

Jing Lu et al. Nat Prod Bioprospect. 2019 Aug.

Abstract

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from the mother liquid. The chemical structures of new compounds (1-4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC50 values ranging from 4.02 to 15.80 μM.

Keywords: Cimicifuga foetida; Cycloartane triterpenoid saponins; Cytotoxic activity.

PubMed Disclaimer

Conflict of interest statement

All authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Structures of compounds 1–8
Fig. 2
Fig. 2
The structure of actein
Fig. 3
Fig. 3
Key correlations in 2D NMR spectra of compound 1
Fig. 4
Fig. 4
Key correlations in 2D NMR spectra of compound 3
Fig. 5
Fig. 5
Key correlations in 2D NMR spectra of compound 4
See this image and copyright information in PMC

References

    1. Guo YQ, Yin T, Wang XM, Zhang F, Pan GX, Lv H, Wang XR, Orgaha JO, Zhua Y, Wu HH. J. Ethnopharmacol. 2017;209:264–282. doi: 10.1016/j.jep.2017.07.040. - DOI - PubMed
    1. Pharmacopoeia Commission of the People’s Republic of China . The Pharmacopoeia of Chinese People’s Republic. Beijing: The Chemical Industry Publishing House; 2015. pp. 68–69.
    1. Einbond LS, Su T, Wu HA, Friedman R, Wang XM, Ramirez A, Kronenberg F, Weinstein IB. Int. J. Cancer. 2007;121:2073–2083. doi: 10.1002/ijc.22897. - DOI - PubMed
    1. Yue GL, Xie SD, Lee KM, Kwok HF, Gao S, Nian Y, Wu XX, Wong CK, Qiu MH, Lau BS. Sci. Rep. 2016;6:35263. doi: 10.1038/srep35263. - DOI - PMC - PubMed
    1. Wu XX, Yue GL, Dong JR, Lam WK, Wong CK, Qiu MH, Lau CB. Front Pharmacol. 2018;9:1466. doi: 10.3389/fphar.2018.01466. - DOI - PMC - PubMed

LinkOut - more resources