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Review
. 2019;34(4):340-346.
doi: 10.1080/08820538.2019.1632355. Epub 2019 Jun 19.

Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy

Stephan Ong Tone  1 , Ula Jurkunas  1
Affiliations
Review

Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy

Stephan Ong Tone et al. Semin Ophthalmol. 2019.

Abstract

Fuchs endothelial corneal dystrophy (FECD) is characterized by the progressive degeneration of the corneal endothelium (CE). The purpose of this article is to review the diagnostic tools available to image and assess the CE in FECD. Slit-lamp biomicroscopy with specular reflection and retroillumination are important techniques to assess the CE. Objective diagnostic tests, such as retroillumination photographic analysis, specular microscopy, in vivo confocal microscopy (IVCM), and anterior segment optical coherence tomography, are valuable tools to evaluate the CE in FECD. Specular microscopy can be performed rapidly without touching the eye but requires a clear cornea with a smooth CE. In contrast, IVCM can image all layers of the cornea, even in advanced FECD. However, IVCM is contact-based and more technically challenging. It is important to select the appropriate objective diagnostic test to image and assess the CE in managing patients with FECD.

Keywords: Confocal; Fuchs; cornea; endothelium; specular.

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Conflict of interest statement

Declaration of interest: None

Figures

Figure 1.
Figure 1.. Slit-lamp photograph using retroillumination in a Fuchs endothelial corneal dystrophy subject.
Confluent guttae (solid arrow head) and individual guttae (double arrow head) are visualized.
Figure 2.
Figure 2.. Non-contact specular microscopy and in vivo confocal microscopy (IVCM) in healthy and Fuchs endothelial corneal dystrophy (FECD) subjects.
(A) Non-contact specular microscopy in a healthy subject. (B) IVCM in a healthy subject. (C) Non-contact specular microscopy in a FECD subject with stage 3 guttae (solid arrowhead) (D) IVCM in a FECD subject with stage 1 guttae (arrow) (E) Non-contact specular microscopy in a FECD subject with stage 2 guttae (solid arrowhead) and stage 3 guttae (double arrowhead) (F) IVCM in a FECD subject with stage 1 guttae (arrow) and stage 2 guttae (solid arrowhead).
See this image and copyright information in PMC

References

    1. Van den Bogerd B, Dhubhghaill SN, Koppen C, Tassignon MJ, Zakaria N. A review of the evidence for in vivo corneal endothelial regeneration. Surv Ophthalmol. 2018;63(2):149–65. 10.1016/j.survophthal.2017.07.004. - DOI - PubMed
    1. Elbaz U, Mireskandari K, Tehrani N, et al. Corneal Endothelial Cell Density in Children: Normative Data From Birth to 5 Years Old. Am J Ophthalmol. 2017;173:134–8. 10.1016/j.ajo.2016.09.036. - DOI - PubMed
    1. Lorenzetti DW, Uotila MH, Parikh N, Kaufman HE. Central cornea guttata. Incidence in the general population. Am J Ophthalmol. 1967;64(6):1155–8. - PubMed
    1. Hamill CE, Schmedt T, Jurkunas U. Fuchs endothelial cornea dystrophy: a review of the genetics behind disease development. Semin Ophthalmol. 2013;28(5–6):281–6. 10.3109/08820538.2013.825283. - DOI - PMC - PubMed
    1. Adamis AP, Filatov V, Tripathi BJ, Tripathi RC. Fuchs’ endothelial dystrophy of the cornea. Surv Ophthalmol. 1993;38(2):149–68. - PubMed

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