Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Oct 15;200(8):954-956.
doi: 10.1164/rccm.201906-1164ED.

Breathing and Ventilation during Extracorporeal Membrane Oxygenation: How to Find the Balance between Rest and Load

Michael Quintel  1 , Mattia Busana  1 , Luciano Gattinoni  1
Affiliations
Editorial

Breathing and Ventilation during Extracorporeal Membrane Oxygenation: How to Find the Balance between Rest and Load

Michael Quintel et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
(A) Mechanical power (MP) normalized per kilogram of body weight delivered during mechanical ventilation before and after onset of extracorporeal membrane oxygenation (ECMO) in the LIFEGARDS (Ventilation Management of Patients with Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome) and EOLIA (Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome) studies, as well as in the experimental study by Araos and colleagues (9), indicating a reduction (in percent) of MP attributed to the respiratory rate (RR) or the Vt. (B) We built a model for an MP (here we use the one delivered during ECMO in the LIFEGARDS study, 6.6 J/min) and a given dead space (200 ml) to establish the best combination of Vt and RR, with the aim of maximizing alveolar ventilation. Each column represents the alveolar ventilation at each different RR (left y-axis), and the light blue line represents the associated Vt (right y-axis). Positive end-expiratory pressure was kept constant (11 cm H2O) in this model, as were the airway resistances. bpm = breaths/min.
See this image and copyright information in PMC

Comment on

References

    1. Schmidt M, Pham T, Arcadipane A, Agerstrand C, Ohshimo S, Pellegrino V, et al. International ECMO Network (ECMONet), and the LIFEGARDS Study Group. Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome: an international multicenter prospective cohort. Am J Respir Crit Care Med. 2019;200:1002–1012. - PubMed
    1. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788–800. [Published erratum appears in JAMA 316:350.] - PubMed
    1. Li X, Scales DC, Kavanagh BP. Unproven and expensive before proven and cheap: extracorporeal membrane oxygenation versus prone position in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2018;197:991–993. - PubMed
    1. Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747–755. - PubMed
    1. Cressoni M, Gotti M, Chiurazzi C, Massari D, Algieri I, Amini M, et al. Mechanical power and development of ventilator-induced lung injury. Anesthesiology. 2016;124:1100–1108. - PubMed