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Comment
. 2019 Jun 18;50(6):1337-1339.
doi: 10.1016/j.immuni.2019.05.018.

The Avidity Game: Selecting Natural-Born Killers

Christopher E Andoniou  1 , Iona S Schuster  1 , Mariapia A Degli-Esposti  2
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Free article
Comment

The Avidity Game: Selecting Natural-Born Killers

Christopher E Andoniou et al. Immunity. .
Free article

Abstract

Natural killer (NK) cells display some features equivalent to those of adaptive immune effectors, but the molecular processes underlying these adaptive-like characteristics are just beginning to be defined. In this issue of Immunity, Adams et al. (2019) and Grassmann et al. (2019) report that avidity selection for Ly49H governs the expansion, differentiation, and function of NK cells after cytomegalovirus infection.

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