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Comment
. 2019 Jun 18;50(6):1339-1341.
doi: 10.1016/j.immuni.2019.05.015.

Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire

Laura C Burzynski  1 , Murray C H Clarke  2
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Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire

Laura C Burzynski et al. Immunity. .
Free article

Abstract

Pyroptotic cell death during endotoxemia causes death via unknown mechanisms. In this issue of Immunity, Wu et al. (2019) show that T3SS rod proteins or LPS induces inflammasome activation, macrophage pyroptosis, and accompanying tissue factor release, directly connecting inflammation to coagulation.

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