An 80,000-Piece Puzzle of Alzheimer's Disease

Tal Iram¹, Andreas Keller², Tony Wyss-Coray³

Affiliations

¹ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
² Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
³ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Veterans Administration Palo Alto Healthcare System, Palo Alto, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. Electronic address: twc@stanford.edu.

PMID: 31216459
DOI: 10.1016/j.immuni.2019.05.016

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An 80,000-Piece Puzzle of Alzheimer's Disease

Tal Iram et al. Immunity. 2019.

Free article

. 2019 Jun 18;50(6):1349-1351.

doi: 10.1016/j.immuni.2019.05.016.

Authors

Tal Iram¹, Andreas Keller², Tony Wyss-Coray³

Affiliations

¹ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
² Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
³ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Veterans Administration Palo Alto Healthcare System, Palo Alto, CA, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. Electronic address: twc@stanford.edu.

PMID: 31216459
DOI: 10.1016/j.immuni.2019.05.016

Abstract

To gain unfettered insight into one of the scourges of our aging societies, Mathys and colleagues in Nature (Mathys et al., 2019) illuminate the brain transcriptome of Alzheimer's disease at single-cell resolution. Their findings implicate oligodendrocytes, a cell type largely neglected in Alzheimer's disease research, and sex in the disease in intriguing ways.

Published by Elsevier Inc.

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Single-cell transcriptomic analysis of Alzheimer's disease.
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Mathys H, et al. Nature. 2019 Jun;570(7761):332-337. doi: 10.1038/s41586-019-1195-2. Epub 2019 May 1. Nature. 2019. PMID: 31042697 Free PMC article.

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An 80,000-Piece Puzzle of Alzheimer's Disease

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An 80,000-Piece Puzzle of Alzheimer's Disease

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Medical