Mitochondrial fission requires DRP1 but not dynamins
- PMID: 31217603
- DOI: 10.1038/s41586-019-1296-y
Mitochondrial fission requires DRP1 but not dynamins
Comment on
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Multiple dynamin family members collaborate to drive mitochondrial division.Nature. 2016 Dec 1;540(7631):139-143. doi: 10.1038/nature20555. Epub 2016 Oct 31. Nature. 2016. PMID: 27798601 Free PMC article.
References
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- Bleazard, W. et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298–304 (1999). - DOI
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- Cereghetti, G. M. et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl Acad. Sci. USA 105, 15803–15808 (2008). - DOI
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- Kalia, R. et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558, 401–405 (2018). - DOI
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- Ji, W. K., Hatch, A. L., Merrill, R. A., Strack, S. & Higgs, H. N. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. eLife 4, e11553 (2015). - DOI
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- Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Multiple dynamin family members collaborate to drive mitochondrial division. Nature 540, 139–143 (2016). - DOI
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