Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Mar;111(1):13-17.
doi: 10.32074/1591-951X-26-17.

Hemangioma of the umbilical cord with associated amnionic inclusion cyst: two uncommon entities occurring simultaneously

G Angelico  1 , S Spadola  1 , A Ieni  2 , A Gurrera  3 , M G Arena  4 , D Arciuolo  1 , M Valente  1 , A Santoro  1 , F Inzani  1 , G F Zannoni  1   5
Affiliations
Case Reports

Hemangioma of the umbilical cord with associated amnionic inclusion cyst: two uncommon entities occurring simultaneously

G Angelico et al. Pathologica. 2019 Mar.

Erratum in

Abstract

Umbilical cord hemangioma is an uncommon benign vascular neoplasm arising from the free segment of the umbilical cord, distinct from placental and fetal insertion, and is thought to originate from endothelial cells of the umbilical vessels. Cystic changes in the umbilical cord rarely occur as a consequence of the damage to the amnionic surface of the cord caused by the presence of the hemangioma. Until now, a total of 8 cases of umbilical cord hemangioma associated with cystic changes in the umbilical cord have been reported in the literature, however, among these cases, only one showed an associated cyst derived from inclusion of the amniotic epithelium, and the remaining seven cases consisted of hemangiomas with associated pseudocyst of the umbilical cord. We herein report a case of umbilical cord hemangioma with an associated amnionic epithelial inclusion cyst. Clinicopathological features and differential diagnostic considerations are also discussed.

Keywords: Amnionic epithelium; Cyst; Hemangioma; Plancenta; Umbilical cord.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

None declared.

Figures

Fig. 1.
Fig. 1.
A) Macroscopic appearance the placenta and umbilical cord. A large cystic mass of 10 cm in greatest diameter can be appreciated in the umbilical cord close to the placental insertion. B) On histological examination, the cystic mass consisted of a single layer of eosinophilic cells. Myxoid degeneration of the cystic wall can also be appreciated. C) Higher magnification of the cyst reveals a single layer of amnionic epithelial cells with flattened or cuboidal morphology (arrow). The epithelial origin of the cyst is confirmed by positive immunostain for pan-cytokeratin antibody (clone AE1/AE3) (inset; D).
Fig. 2.
Fig. 2.
A) Photomicrograph of the hemagioma showing multiple round or elongated, vascular channel surrounding the umbilical artery (UA) (Stain: Haematoxylin and Eosin). B) The neoplastic vessels seem to originate and radiate from the umbilical artery (arrow). C) The neoplastic vascular channels are embedded in a dense myxoid stroma and show diffuse immunohistochemical staining for CD31 antibody (D).
See this image and copyright information in PMC

References

    1. George A, Mani V, Noufal A. Update on the classification of hemangioma. J Oral Maxillofac Pathol 2014;18:117-20. - PMC - PubMed
    1. Ghidini A, Romero R, Eisen RN, et al. . Umbilical cord hemangioma. Prenatal identification and review of the literature. J Ultrasound Med 1990;9:297-300. - PubMed
    1. Heifetz SA, Rueda-Pedraza ME. Hemangiomas of the umbilical cord. Pediatr Pathol 1983;1:385-98. - PubMed
    1. Nguyen M, Addicott B, Chu J, et al. . Congenital cyst of the umbilical cord. Fetal Pediatr Pathol 2016;5:1-4. - PubMed
    1. Yavner DL, Redline RW. Angiomyxoma of the umbilical cord with massive cystic degeneration of Wharton’s jelly. Arch Pathol Lab Med 1989;113:935-7. - PubMed

Publication types