Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec;16(2):162-169.

PATTERN OF MULTIDRUG RESISTANT BACTERIA ASSOCIATED WITH INTENSIVE CARE UNIT INFECTIONS IN IBADAN, NIGERIA

O B Makanjuola  1   2 , S A Fayemiwo  1   2 , A O Okesola  1   2 , A Gbaja  2 , V A Ogunleye  2 , A O Kehinde  1 , R A Bakare  1   2
Affiliations

PATTERN OF MULTIDRUG RESISTANT BACTERIA ASSOCIATED WITH INTENSIVE CARE UNIT INFECTIONS IN IBADAN, NIGERIA

O B Makanjuola et al. Ann Ib Postgrad Med. 2018 Dec.

Abstract

Background: Patients admitted into the intensive care unit (ICU) usually have impaired immunity and are therefore at high risk of acquiring hospital associated infections. Infections caused by multidrug resistant organisms now constitute a major problem, limiting the choice of antimicrobial therapy.

Objectives: This study was aimed at determining the antimicrobial resistance pattern of pathogens causing ICU infections in University College Hospital (UCH), Ibadan, Nigeria. The aetiological agents, prevalence and types ICU infections were also determined.

Methods: One year hospital associated infections surveillance was conducted in the ICU of UCH, Ibadan. Blood, urine, tracheal aspirate and wound biopsies specimens were collected under strict asepsis and sent to the Medical Microbiology laboratory of the same institution for immediate processing. All pathogens were isolated and identified by standard microbiological methods. Disk diffusion antibiotic susceptibility testing was performed and interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines.

Results: The overall prevalence of ICU infections was 30.9% out of which 12.9% were bloodstream infections, 31.5% urinary tract infections, 38.9% pneumonia, and 16.7% skin and soft tissue infections. Klebsiella species andEscherichia coli were the predominant pathogens. Multidrug resistant organisms constituted 59.3% of the pathogens, MDR Klebsiella spp and MDR E. coli were 70.8% and 71.4% respectively. Resistance to Cefuroxime was the highest (92.9%) while Meropenem had the least resistance (21.4%).

Conclusion: There is a high prevalence of multidrug resistant bacteria causing ICU infections. Application of more stringent infection control procedures and institution of functional antimicrobial stewardship are recommended to combat this problem.

Keywords: Antibiotic resistance; Healthcare associated infections; Infection control; Intensive care unit..

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rothe C, Schlaich C, Thompson S. Healthcareassociated infections in sub-Saharan Africa. J Hosp Infect. 2013;85(4):257–267. - PubMed
    1. Khan HA, Ahmad A, Mehboob R. Nosocomial infections and their control strategies. Asian Pac J Trop Biomed. 2015;5(7):509–514.
    1. Eggimann P, Pittet D. Infection control in the ICU. Chest. 2001;120 - PubMed
    1. Hani U, Shivakumar HG, Vaghela R, et al. Candidiasis: a fungal infection current challenges and progress in prevention and treatment. [Accessed April 17 2018];Infect Disord Drug Targets. 2015 15(1):42–52. http:// www.ncbi.nlm.nih.gov/pubmed/25809621. - PubMed
    1. Bartlett JG, Gerding DN. Clinical Recognition and Diagnosis of Clostridium difficile Infection. Clin Infect Dis. 2008;46(s1):S12–S18. - PubMed

LinkOut - more resources