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. 2019 May 15;11(5):3167-3175.
eCollection 2019.

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension

Yameng Cui  1 , Zhenyu Zhu  1 , Xin Qi  2 , Huihui Li  1 , Yulin Wu  1 , Wanli Chen  1 , Yue Liu  2
Affiliations

Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension

Yameng Cui et al. Am J Transl Res. .

Abstract

Background: Left ventricular hypertrophy (LVH) is the most common structural damage in hypertensive complication and is an independent risk factor for assessing cardiovascular events. The aim of this study was explore the relationship between plasma concentration of angiotensin II (Ang II), Adrenomedulin (ADM) and adrenotensin (ADT) in patients with hypertension and LVH.

Methods: We enrolled 310 hypertensive patients from the department of cardiology of Tianjin Union Medical Center as the hypertension group and 39 healthy subjects as control group. Further grouping according to the LVMI (male LVMI≥115 g/m2, female LVMI≥95 g/m2) values for determining LVH in the 2013 ESC Hypertension Management Guidelines. Plasma levels of Ang II, ADM and ADT were measured using ELISA assay.

Results: The levels of plasma Ang II and ADM in essential hypertension (EH) were significantly higher than control group, and the essential hypertension combined left ventricular hypertrophy (EHCLVH) group was higher than essential hypertension not with left ventricular hypertrophy (EHNLVH) group (P<0.05). Correlation analyze showed that left ventricular mass index (LVMI) was positively related to Ang II and ADM, and negatively related to ADT. Logistic regression analyze indicated that LVH are strongly linked with systolic blood pressure (SBP), Ang II, ADM and ADT. ROC curve showed ADM and ADT have similar value in distinguish LVH.

Conclusion: Plasma levels of Ang II, ADM and ADT might act as indicator to identify hypertensive LVH.

Keywords: Hypertension; adrenomedulin; adrenotensin; angiotensin II; left ventricular hypertrophy.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The value of LVMI and plasma levels of Ang II, ADM and ADT. *P<0.05 **P<0.01 vs. Control group.
Figure 2
Figure 2
Correlation analysis of LVMI with Ang II, ADM and ADT. P<0.05 indicates statistically significant.
Figure 3
Figure 3
ROC curve for diagnosis hypertensive LVH.
See this image and copyright information in PMC

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