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Meta-Analysis
. 2019 Aug;12(3):194-199.
doi: 10.1111/jebm.12355. Epub 2019 Jun 20.

Celiac disease and risk of sarcoidosis: A systematic review and meta-analysis

Karn Wijarnpreecha  1   2 , Panadeekarn Panjawatanan  3 , Juan E Corral  2 , Frank J Lukens  2 , Patompong Ungprasert  4
Affiliations
Meta-Analysis

Celiac disease and risk of sarcoidosis: A systematic review and meta-analysis

Karn Wijarnpreecha et al. J Evid Based Med. 2019 Aug.

Abstract

Background/objectives: Several epidemiologic studies have suggested that patients with celiac disease may be at an increased risk of sarcoidosis but the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to better characterize this risk by summarizing all available data.

Methods: A literature review was performed using MEDLINE and EMBASE database from inception to February 2019. Studies that compared the risk of sarcoidosis among patients with celiac disease versus individuals without celiac disease were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results: Of 426 retrieved studies, four studies with 693 639 participants met the eligibility criteria and were included in meta-analysis. The risk of sarcoidosis among patients with celiac disease was higher than individuals without celiac disease with the pooled OR of 7.16 (95% CI, 1.48-34.56). The statistical heterogeneity of this study was high (I2 = 95%).

Conclusions: This systematic review and meta-analysis found a significantly higher risk of sarcoidosis among patients with celiac disease.

Keywords: analysis celiac disease; enteropathy; gluten meta sarcoidosis.

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REFERENCES

    1. Peters U, Askling J, Gridley G, Ekbom A, Linet M. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Internal Med. 2003;163(13):1566-1572.
    1. Gadewar S, Fasano A. Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances. Curr Gastroenterol Rep. 2005; 7(6): 455-461.
    1. Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012;107(10):1538-1544. quiz.
    1. Singh P, Arora S, Singh A, Strand TA, Makharia GK. Prevalence of celiac disease in Asia: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2016;31(6):1095-1101.
    1. Tatar G, Elsurer R, Simsek H, et al. Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population. Digest Dis Sci. 2004;49(9):1479-1484.

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