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Comparative Study
. 1978 Dec;12(4):233-43.

Effect of insulin on RNA and protein biosynthesis in liver mitochondria from normal and alloxan diabetic rats

Y L Germanyuk, A G Minchenko
  • PMID: 312194
Comparative Study

Effect of insulin on RNA and protein biosynthesis in liver mitochondria from normal and alloxan diabetic rats

Y L Germanyuk et al. Endocrinol Exp. 1978 Dec.

Abstract

In liver mitochondria from alloxan diabetic rats the biosynthesis of RNA (as measured by 14C-orotic acid incorporation and RNA polymerase activity) and protein (as measured by 14C-leucine incorporation) were decreased. In contrast, insulin (20 U kg-1) injected to intact or diabetic rats increased both these measures. However, no change of mitochondrial DNA biosynthesis (as measured by incorporation of 3H-thymidine) was found. It was concluded that in liver cells insulin plays an important role in regulation of biosynthesis not only of nuclear (cytoplasmic) but also of mitochondrial RNA and proteins.

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