When medicine transforms art
- PMID: 31220394
- DOI: 10.1111/tid.13130
When medicine transforms art
Abstract
A 40-year-old female with a history of type 1 diabetes mellitus and solitary pancreas transplant, presented with pancreatic graft rejection 1-year post-transplant. Incidentally, a 1.1 cm right lower lobe cavity was identified during her workup. Given the augmentation of immunosuppression, voriconazole was empirically started for possible invasive pulmonary aspergillosis. As the patient was a painter, this resulted in a significant change in the colors of her paintings. Ultimately, she was diagnosed with pulmonary coccidioidomycosis and her visual disturbances resolved after the voriconazole was changed to fluconazole. Voriconazole causes visual disturbances in 20%-30% of the patients most commonly phototopsias; dyschromatopsias typically involving the tritan axis have also been reported. This case illustrates well the potential impact of voriconazole on spectral sensitivity and color perception.
Keywords: art painting; coccidioidomycosis; visual disturbances; voriconazole.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
References
REFERENCES
-
- Zonios DI, Gea-Banacloche J, Childs R, Bennett JE. Hallucinations during voriconazole therapy. Clin Infect Dis. 2008;47(1):e7-e10.
-
- Mounier A, Agard E, Douma I, et al. Macular toxicity and blind spot enlargement during a treatment by voriconazole: a case report. Eur J Ophthalmol. 2018;28(4):NP11-NP14.
-
- Zrenner E, Tomaszewski K, Hamlin J, Layton G, Wood N. Effects of multiple doses of voriconazole on the vision of healthy volunteers: a double-blind, placebo-controlled study. Ophthalmic Res. 2014;52(1):43-52.
-
- Bayhan GI, Garipardic M, Karaman K, Akbayram S. Voriconazole-associated visual disturbances and hallucinations. Cutan Ocul Toxicol. 2016;35(1):80-82.
-
- Xiong WH, Brown RL, Reed B, Burke NS, Duvoisin RM, Morgans CW. Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels. Invest Ophthalmol Vis Sci. 2015;56(2):1367-1373.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
