Review
doi: 10.1146/annurev-biochem-013118-111042.
The Organizing Principles of Eukaryotic Ribosome Recruitment
Affiliations
- PMID: 31220979
- DOI: 10.1146/annurev-biochem-013118-111042
Item in Clipboard
Review
The Organizing Principles of Eukaryotic Ribosome Recruitment
Annu Rev Biochem.
.
Abstract
The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the encoded polypeptide product. In most circumstances, this step commits the ribosome to translate the mRNA. We summarize the knowledge regarding the initiation factors implicated in this activity as well as review different mechanisms by which this process is conducted.
Keywords: eIF4A; eIF4B; eIF4E; eIF4F; eIF4G; eIF4H; eukaryotic initiation factors; ribosome recruitment; translation.
Similar articles
-
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.Annu Rev Biochem. 1999;68:913-63. doi: 10.1146/annurev.biochem.68.1.913. Annu Rev Biochem. 1999. PMID: 10872469 Review.
-
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.Mol Cell. 1998 Sep;2(3):383-8. doi: 10.1016/s1097-2765(00)80282-8. Mol Cell. 1998. PMID: 9774976
-
eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G.Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10464-72. doi: 10.1073/pnas.1612398113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601676 Free PMC article.
-
eIF4G: a multipurpose ribosome adapter?Science. 1997 Jan 24;275(5299):500-1. doi: 10.1126/science.275.5299.500. Science. 1997. PMID: 9019810 Review. No abstract available.
-
Ribosome binding to inosine-substituted mRNAs in the absence of ATP and mRNA factors.J Biol Chem. 1989 May 5;264(13):7363-8. J Biol Chem. 1989. PMID: 2708369
Cited by
-
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation.Nat Struct Mol Biol. 2023 Nov;30(11):1816-1825. doi: 10.1038/s41594-023-01119-z. Epub 2023 Nov 13. Nat Struct Mol Biol. 2023. PMID: 37957305
-
Structural analysis of the Trypanosoma brucei EIF4E6/EIF4G5 complex reveals details of the interaction between unusual eIF4F subunits.Sci Rep. 2024 Jan 25;14(1):2178. doi: 10.1038/s41598-024-52364-1. Sci Rep. 2024. PMID: 38272944 Free PMC article.
-
Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation.PLoS Pathog. 2023 Nov 20;19(11):e1011417. doi: 10.1371/journal.ppat.1011417. eCollection 2023 Nov. PLoS Pathog. 2023. PMID: 37983287 Free PMC article.
-
5'-Cap‒Dependent Translation as a Potent Therapeutic Target for Lethal Human Squamous Cell Carcinoma.J Invest Dermatol. 2021 Apr;141(4):742-753.e10. doi: 10.1016/j.jid.2020.08.021. Epub 2020 Sep 21. J Invest Dermatol. 2021. PMID: 32971126 Free PMC article.
-
Mechanisms of action of triptolide against colorectal cancer: insights from proteomic and phosphoproteomic analyses.Aging (Albany NY). 2022 Apr 2;14(7):3084-3104. doi: 10.18632/aging.203992. Epub 2022 Apr 2. Aging (Albany NY). 2022. PMID: 35366242 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
