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Observational Study
. 2019 Jun 20;19(1):109.
doi: 10.1186/s12890-019-0870-2.

Validation of the Multi-INdependence Dimensions (MIND) questionnaire for prolonged mechanically ventilated subjects

Joao C Winck  1   2 , Hélène Gilet  3 , Peter Kalin  4 , Javier Murcia  5 , Fabian Plano  6 , Antoine Regnault  3 , Michael Dreher  7 , Michele Vitacca  8 , Nicolino Ambrosino  9
Affiliations
Observational Study

Validation of the Multi-INdependence Dimensions (MIND) questionnaire for prolonged mechanically ventilated subjects

Joao C Winck et al. BMC Pulm Med. .

Abstract

Background: Evaluating severity of illness of patients with prolonged mechanical ventilation (PMV) is important to adopt the best appropriate care management for each individual. Yet, no severity-of-illness scoring system has been specifically designed for this type of patients. The aim of this study was to develop and validate a new instrument, the Multi-INdependence Dimensions (MIND) questionnaire designed to comprehensively measure the severity of illness of patients under PMV.

Methods: The validation of the MIND questionnaire was performed during a longitudinal observational study conducted with PMV subjects in weaning facilities in three countries (Argentina, Colombia and Germany). The questionnaire validity was tested in 3 stages: 1) Specification of components, with description of item responses, inter-item and Cronbach alpha correlations; 2) Creation of the composite scores; 3) Measurement properties determination including test-retest reliability after 30 days, clinical validity (Medical Research Council (MRC) muscle strength score, Sepsis-related Organ Failure Assessment (SOFA), Glasgow Coma Scale (GCS), Dependence Nursing Scale and EuroQol-5 Dimension evaluated at inclusion), and ability to detect change.

Results: A total of 128 subjects participated in the validation study. Eleven component scores and four composite scores were created. MIND scores significantly correlated with MRC muscle strength, SOFA, DNS, GCS and EQ-5D, supporting the validity of the new scores. Intraclass Correlation Coefficient greater than 0.82 were observed for all composite scores, indicating good test-retest reliability. MIND scores were able to detect improvement in subject severity of illness.

Conclusion: The MIND questionnaire is a valid and reliable instrument for measuring comprehensively the multiple dimensions characterizing the severity of illness of PMV patients.

Trial registration: NCT02255058 .

Keywords: Composite scores; Health status assessment; MIND questionnaire; Prolonged mechanical ventilation; Questionnaire validation; Rehabilitation.

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Conflict of interest statement

NA has no conflict of interest to disclose. HG and AR were paid consultant to Linde AG. MD received honoraria from Linde AG, ResMed, Respironics, Weinmann, Heinen und Löwenstein, Hamilton for participations in advisory boards and lectures. MV received honoraria from Linde AG during the conduct of the study. PK, JCW, JM and FP were employees of Linde AG during the conduct of the study. JCW is currently an Associate Editor for BMC Pulmonary Medicine.

Figures

Fig. 1
Fig. 1
Analysis strategy
Fig. 2
Fig. 2
Study flow chart
Fig. 3
Fig. 3
Responses to MIND items at baseline (N = 128)
Fig. 4
Fig. 4
Comparison of MIND composite scores at baseline according to MRC scores, SOFA score and GCS (N = 128)
See this image and copyright information in PMC

References

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