Structures Unveil the Invasion Mechanism of Chikungunya Virus

Qiu Sun¹, Xiao Du², Wei Cheng³

Affiliations

¹ Division of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China.
² Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China; Department of General Surgery, Yaan People's Hospital, Yaan 625000, Sichuan, China. Electronic address: duxiao_home@163.com.
³ Division of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China. Electronic address: chengwei669@scu.edu.cn.

PMID: 31221449
DOI: 10.1016/j.tim.2019.05.011

Comment

Structures Unveil the Invasion Mechanism of Chikungunya Virus

Qiu Sun et al. Trends Microbiol. 2019 Aug.

. 2019 Aug;27(8):656-658.

doi: 10.1016/j.tim.2019.05.011. Epub 2019 Jun 17.

Authors

Qiu Sun¹, Xiao Du², Wei Cheng³

Affiliations

¹ Division of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China.
² Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China; Department of General Surgery, Yaan People's Hospital, Yaan 625000, Sichuan, China. Electronic address: duxiao_home@163.com.
³ Division of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, Sichuan, China. Electronic address: chengwei669@scu.edu.cn.

PMID: 31221449
DOI: 10.1016/j.tim.2019.05.011

Erratum in

Structures Unveil the Invasion Mechanism of Chikungunya Virus.
Sun Q, Du X, Cheng W. Sun Q, et al. Trends Microbiol. 2020 Jan;28(1):84. doi: 10.1016/j.tim.2019.11.001. Epub 2019 Nov 25. Trends Microbiol. 2020. PMID: 31780230 No abstract available.

Abstract

Structures of the multiple arthritogenic alphavirus receptor MXRA8 as well as MXRA8 in complex with chikungunya virus (Song et al., Cell, 2019; Basore et al., Cell, 2019) have revealed the mechanism underlying viral invasion and could facilitate the development of novel vaccines and entry inhibitors.

Keywords: MXRA8 receptor; alphaviruses; cryo-EM structure.

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Comment on

Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH. Basore K, et al. Cell. 2019 Jun 13;177(7):1725-1737.e16. doi: 10.1016/j.cell.2019.04.006. Epub 2019 May 9. Cell. 2019. PMID: 31080061 Free PMC article.
Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.
Song H, Zhao Z, Chai Y, Jin X, Li C, Yuan F, Liu S, Gao Z, Wang H, Song J, Vazquez L, Zhang Y, Tan S, Morel CM, Yan J, Shi Y, Qi J, Gao F, Gao GF. Song H, et al. Cell. 2019 Jun 13;177(7):1714-1724.e12. doi: 10.1016/j.cell.2019.04.008. Epub 2019 May 9. Cell. 2019. PMID: 31080063

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Structures Unveil the Invasion Mechanism of Chikungunya Virus

Affiliations

Structures Unveil the Invasion Mechanism of Chikungunya Virus

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