Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jun 21;364(6446):1132-1133.
doi: 10.1126/science.aax9341.

Hiding in plain sight

Affiliations
Comment

Hiding in plain sight

Christopher J Halbrook et al. Science. .
No abstract available

PubMed Disclaimer

Figures

None
Signaling underlying pancreatic disease
Posttranslational modifications by CA19–9 can confer new functions to proteins. CA19–9:fibulin-3 can act as an EGFR ligand, thereby activating the downstream RAS-RAF-MEK-ERK signaling cascade.

Comment on

  • The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
    Engle DD, Tiriac H, Rivera KD, Pommier A, Whalen S, Oni TE, Alagesan B, Lee EJ, Yao MA, Lucito MS, Spielman B, Da Silva B, Schoepfer C, Wright K, Creighton B, Afinowicz L, Yu KH, Grützmann R, Aust D, Gimotty PA, Pollard KS, Hruban RH, Goggins MG, Pilarsky C, Park Y, Pappin DJ, Hollingsworth MA, Tuveson DA. Engle DD, et al. Science. 2019 Jun 21;364(6446):1156-1162. doi: 10.1126/science.aaw3145. Science. 2019. PMID: 31221853 Free PMC article.

References

    1. Herlyn M, Sears HF, Steplewski Z, Koprowski H, J. Clin. Immunol 2, 135 (1982). - PubMed
    1. Engle DD et al., Science 364, 1156 (2019). - PMC - PubMed
    1. Tempero MA et al., Cancer Res 47, 5501 (1987). - PubMed
    1. Gebauer F et al., Gut 62, 741 (2013). - PubMed
    1. Miyazaki K et al., Cancer Res 64, 4498 (2004). - PubMed

Publication types

Substances