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. 2018 Dec 21;14(9):511-520.
doi: 10.6026/97320630014511. eCollection 2018.

Antibacterial Activity study of Musizin isolated from Rhamnus wightii Wight and Arn

William Raja Tharsius Raja  1 , Stalin Antony  2   3 , SaravanaKumar Pachaiyappan  4 , Jackson Amalraj  4 , Poorva Narasimhan  3 , Balakrishna Keduki  1 , Duraipandiyan Veeramuthu  4   5 , Palani Perumal  3 , Ignacimuthu Savarimuthu  1   6
Affiliations

Antibacterial Activity study of Musizin isolated from Rhamnus wightii Wight and Arn

William Raja Tharsius Raja et al. Bioinformation. .

Abstract

The crude extracts and the compounds isolated from traditional medicinal plants are used to treat infectious diseases caused by bacteria, fungi, and viruses. An attempt has been made in the present investigation to evaluate the antibacterial activity of musizin isolated from Rhamnus wightii, (Family: Rhamnaceae) against Gram-positive (Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis), and Gramnegative (Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa) bacteria. The tested compound showed more pronounced antibacterial activity against the tested pathogens than the standard antibiotics like streptomycin and gentamycin with the lowest minimum inhibitory concentration (MIC). Molecular docking analysis was performed to study the effectiveness of musizin compared to the standard antibiotics; it showed a significant interaction with the target proteins such asalgR (P. arginosa), divIVA (E. faecalis), icaA (S. aureus), plcR(B. cereus), treC (K. pneumonia) and ftsl (E. coli) and found that musizin showed higher potential with least binding energy. It has also been found that musizin had better ADMET properties than the standard drugs. Thus,musizin acts as an inhibitor of bacterial growth for consideration as a drug to treat bacterial infections.

Keywords: Musizin; Rhamnus wightii; antibacterial activity; in silico analysis; target receptors.

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Figures

Figure 1
Figure 1
TLC profile and chemical structure of musizin from R. wightii
Figure 2
Figure 2
Antibacterial activity of different organic solvent extracts of R. wightii against human pathogenic bacteria
Figure 3
Figure 3
Determination of Minimum Inhibitory Concentration for purified Musizin (A) and standard antibiotics, gentamycin and streptomycin (B). K. Pneumonia showed highest sensitivity against Musizin at 120 µg per mL concentration.
Figure 4
Figure 4
The figure represents the homology model of target proteins such asAlgR (a), divIVA (b), icaA (c), plcR (d), treC (e) and ftsl (f).
See this image and copyright information in PMC

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