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Review
. 2019 Jun 13:24:40.
doi: 10.1186/s11658-019-0164-y. eCollection 2019.

Progress in research on paclitaxel and tumor immunotherapy

Linyan Zhu  1 , Liqun Chen  1
Affiliations
Review

Progress in research on paclitaxel and tumor immunotherapy

Linyan Zhu et al. Cell Mol Biol Lett. .

Abstract

Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments.

Keywords: Anticancer mechanism; Biosynthetic pathway; Endophytic fungus; Paclitaxel.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Chemical structure of paclitaxel
Fig. 2
Fig. 2
The biosynthetic pathway of paclitaxel
See this image and copyright information in PMC

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